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| Product | Description | |
|---|---|---|
| Fasudil dihydrochloride | Fasudil (HA-1077; AT877) dihydrochloride is a nonspecific RhoA/ROCK inhibitor and also has inhibitory effect on protein kinases, with an Ki of 0.33 μM for ROCK1, IC50s of 0.158 μM and 4.58 μM, 12.30 μM, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively. Fasudil dihydrochloride is also a potent Ca2+ channel antagonist and vasodilator. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 203911-27-7. Molecular formula: C14H17N3O2S.2ClH. Mole weight: 364.29. Product ID: ACM203911277. Alfa Chemistry ISO 9001:2015 Certified. |  |
| HA-1077 dihydrochloride | HA-1077 is a potent and selective inhibitor of Rho kinase (ROCK). HA-1077 exhibited neuroprotective effects and enhanced cognition in mouse models of amyotrophic lateral sclerosis (ALS), suggesting its potential use for cognitive disorders such as ALS, Alzheimer's disease and spinal muscular atrophy. It also suppresses tumor cell motility and metastasis. Synonyms: Fasudil dihydrochloride; 5-((1,4-Diazepan-1-yl)sulfonyl)isoquinoline dihydrochloride. Grades: ≥98%. CAS No. 203911-27-7. Molecular formula: C14H17N3O2S·2HCl. Mole weight: 364.3. |  |
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