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It is an anticancer antibiotic first isolated from S. cyaneogriseus ssp. noncyanogenus (LL-F28249). It has more selective action against mammalian tumour cell lines than Oligomycin A, exhibiting only weak antifungal and nematocidal activity. Synonyms: Nemadectin omega; LL-F28249 omega; (1R, 2'S, 4E, 5'S, 6S, 6'S, 7R, 8S, 10R, 11R, 12S, 14R, 15S, 16R, 18E, 20E, 22R, 25S, 28S, 29R)-22-Ethyl-3', 4', 5', 6'-tetrahydro-7, 11, 14, 15, 23-pentahydroxy-6'-[(2R)-2-hydroxypropyl]-5', 6, 8, 10, 12, 14, 16, 28, 29-nonamethylspiro[2, 26-dioxabicyclo[23.3.1]nonacosa-4, 18, 20-triene-27, 2'-[2H]pyran]-3, 9, 13-trione. Grades: >95% by HPLC. CAS No. 102042-09-1. Molecular formula: C45H74O12. Mole weight: 807.06.
21-hydroxyoligomycin A (Nemadectin omega, Antibiotic LL-F28249 omega)
21-Hydroxyoligomycin A is a rare member of the oligomycin class isolated as a co-metabolite of nemadectin, hence its original naming as nemadectin omega. Only limited literature references to this metabolite are available. However, in-house testing suggests that 21-hydroxyoligomycin has a more selective action against mammalian tumor cell lines than oligomycin A, exhibiting only weak antifungal and nematocidal activity. Group: Biochemicals. Alternative Names: Nemadectin omega, Antibiotic LL-F28249 omega. Grades: Highly Purified. CAS No. 102042-09-1. Pack Sizes: 1mg. US Biological Life Sciences.
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