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| Product | Description | |
|---|---|---|
| Gemcitabine 5'-elaidate | Gemcitabine 5'-elaidate. Group: Biochemicals. Alternative Names: (E)-((2R,3R,5R)-5-(4-Amino-2-oxopyrimidin-1(2H)-yl)-4,4-difluoro-3-hydroxytetrahydrofuran-2-yl)methyl octadec-9-enoate; 2'-Deoxy-2',2'-difluorocytidine 5'-(9E)-9-octadecenoate; CP-4126; LVT derivative of Gemcitabine; CO-101. Grades: Highly Purified. CAS No. 210829-30-4. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C27H43F2N3O5. US Biological Life Sciences. |  Worldwide |
| Gemcitabine elaidate | Gemcitabine elaidate (also known as CO-101; CP-4126) is a lipophilic, unsaturated fatty acid ester derivative of gemcitabine (dFdC), an antimetabolite deoxynucleoside analogue, with potential antineoplastic activity. Upon hydrolysis intracellularly by esterases, the prodrug gemcitabine is converted into the active metabolites difluorodeoxycytidine di- and tri-phosphate (dFdCDP and dFdCTP) by deoxycytidine kinase. dFdCDP inhibits ribonucleotide reductase, thereby decreasing the deoxynucleotide pool available for DNA synthesis; dFdCTP is incorporated into DNA, resulting in DNA strand termination and apoptosis. Due to its lipophilicity, gemcitabine 5'-elaidic acid ester exhibits an increased cellular uptake and accumulation, resulting in an increased conversion to active metabolites, compared to gemcitabine. In addition, this formulation of gemcitabine may be less susceptible to deamination and deactivation by deoxycytidine deaminase. Synonyms: CO-101; CO101; CO 101; CP-4126; CP4126; CP 4126. CAS No. 210829-30-4. Molecular formula: C27H43F2N3O5. Mole weight: 527.654. |  |
| Gemcitabine elaidate | Gemcitabine elaidate (CP-4126) is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate is converted to Gemcitabine by esterases in order to be phosphorylated. Gemcitabine elaidate exhibits anti-tumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-4126; CO-101; Gemcitabine 5'-elaidate. CAS No. 210829-30-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13538. |  |
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