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| Product | Description | |
|---|---|---|
| 1400W dihydrochloride | 1400W is a selective inducible nitric oxide synthase (NOS) inhibitor (Ki=7nM). By suppressing the induction of inducible NOS, 1400W exhibits an therapeutical effect on ischemia reperfusion injury, acute hypobaric hypoxia/reoxygenation-induced cognitive deficits and tumor. Uses: A selective inducible nitric oxide synthase (inos) inhibitor which has the potential for treatment of ischemia reperfusion injury,acute hypobaric hypoxia and tumor. Synonyms: N-[[3-(aminomethyl)phenyl]methyl]-ethanimidamide, dihydrochloride; 1400W HCl; 1400W hydrochloride; 1400W (hydrochloride). Grades: >98%. CAS No. 214358-33-5. Molecular formula: C10H17Cl2N3. Mole weight: 250.167. |  |
| 1400W Dihydrochloride | 1400W dihydrochloride is the dihydrochloride form of 1400W (HY-18730). 1400W is a slow, tight binding, and highly selective inducible nitric-oxide synthase ( iNOS ) inhibitor, with a K d value ≤ 7 nM. 1400W inhibits iNOS induction in microglial cells, and reduces generation of NO, thereby mitigating oxidative stress and neuronal cell apoptosis in the rat cerebral cortex, and improving the spatial memory dysfunction caused by acute hypobaric hypoxia-reoxygenation [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 214358-33-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18731. |  |
| 1400W Dihydrochloride | Cell-permeable. A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd ≤7nM). In contrast, inhibition of nNOS and eNOS is weaker and rapidly reversible with K? values of 2 and 50uM respectively. Inhibits tumor growth in vivo. Prevents circulatory failure but not organ injury induced by endotoxin. Displays protective effects in oxygen-deprived brain slices. Group: Biochemicals. Alternative Names: N- (3- (Aminomethyl) benzyl) acetamidine 2HCl. Grades: Highly Purified. CAS No. 214358-33-5. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. |  Worldwide |
| 1400W dihydrochloride (N- (3- (Aminomethyl) benzyl) acetamidine. 2HCl) | A slow, tight binding and highly selective inhibitor of iNOS (inducible nitric oxide synthase/NOS II) (Kd < 7 nM). Weak and reversible inhibition of nNOS (neuronal nitric oxide synthase/NOS I) (Ki < 2) and eNOS (endothelial nitric oxide synthase/NOS III) (Ki < 50 µM). Inhibits tumor growth. Increases vasoconstriction to noradrenaline. Improves contractile function. Improves stroke outcome and decreases glutamate release. Anti-inflammatory. Group: Biochemicals. Alternative Names: N- (3- (Aminomethyl) benzyl) acetamidine. 2HCl. Grades: Highly Purified. CAS No. 214358-33-5. Pack Sizes: 5mg, 25mg, 100mg. Molecular Formula: C10H15N3. 2HCl. US Biological Life Sciences. | Worldwide |
| Acetamidine Impurity 4 | Acetamidine Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 214358-33-5. Molecular Formula: C10H17Cl2N3. Mole Weight: 250.17. Catalog: APB214358335. |  |
| N- (3- (Aminomethyl) benzyl) acetamidine dihydrochloride | Inhibitor of inducible nitric oxide synthase. Group: Biochemicals. Alternative Names: N- [ [3- (Aminomethyl) phenyl] methyl] ethanimidamide dihydrochloride; 1400W. Grades: Highly Purified. CAS No. 214358-33-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C10H17Cl2N3. US Biological Life Sciences. | Worldwide |
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