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| Product | Description | |
|---|---|---|
| Adagrasib | Adagrasib (MRTX849) is a potent, orally-available, and mutation-selective covalent inhibitor of KRAS G12C with potential antineoplastic activity. Adagrasib covalently binds to KRAS G12C at the cysteine at residue 12, locks the protein in its inactive GDP-bound conformation, and inhibits KRAS-dependent signal transduction [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MRTX849. CAS No. 2326521-71-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-130149. |  |
| MRTX849 | MRTX849 Inhibitor. Uses: Scientific use. Product Category: T8369. CAS No. 2326521-71-3. |  |
| MRTX849 | MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. Uses: Antineoplastic agents. Synonyms: MRTX-849; MRTX 849; Adagrasib; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile. CAS No. 2326521-71-3. Molecular formula: C32H35ClFN7O2. Mole weight: 604.12. |  |
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