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24(S)-Hydroxycholesterol (24S-OHC), the major brain cholesterol metabolite, plays an important role to maintain homeostasis of cholesterol in the brain. 24(S)-Hydroxycholesterol (24S-OHC) is one of the most efficient endogenous LXR agonist known and is present in the brain and in the circulation at relatively high levels. 24(S)-Hydroxycholesterol (24S-OHC) is a very potent, direct, and selective positive allosteric modulator of NMDARs with a mechanism that does not overlapthat of other allosteric modulators [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 24S-OHC; 24S-HC; Cerebrosterol. CAS No. 474-73-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-16940.
24(S)-Hydroxycholesterol
(3β,24S)-Cholest-5-ene-3,24-diol is used as a biomarker in the analysis of disease. Synonyms: Cerebrosterol; Cholest-5-ene-3,24-diol; 24S-hydroxycholesterol; cholest-5-en-3beta,24S-diol; (24S)-cholest-5-ene-3beta,24-diol. Grade: > 95%. CAS No. 474-73-7. Molecular formula: C27H46O2. Mole weight: 402.65.
24-Hydroxycholesterol, also known as 24-OH-Chol, a natural sterol, is the main cholesterol elimination product of the brain. 24-Hydroxycholesterol is a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR. 24-Hydroxycholesterol acts as a neurotoxin to SH-SY5Y human neuroblastoma cells which showed corresponding morphological changes: the cells became round, lost adhesion to the petri-dish, and neurite outgrowth degenerated. Synonyms: (3S,8S,9S,10R,13R,14S,17R)-17-[(2R)-5-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol; 24-hydroxycholesterol; 24S-hydroxycholesterol; cerebrosterol; cholest-5-ene-3,24-diol. CAS No. 30271-38-6. Molecular formula: C27H46O2. Mole weight: 402.65.
24-Hydroxycholesterol
24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR , and a potent activator of the transcription factors LXR. Uses: Scientific research. Group: Natural products. CAS No. 30271-38-6. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg. Product ID: HY-N2370.
24-hydroxycholesterol 7α-hydroxylase
A P450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium. The enzyme is specific for (24S)-cholest-5-ene-3β,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: 24-hydroxycholesterol 7α-monooxygenase; CYP39A1; CYP39A1 oxysterol 7α-hydroxylase. Enzyme Commission Number: EC 1.14.14.26. CAS No. 288309-90-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0923; 24-hydroxycholesterol 7α-hydroxylase; EC 1.14.14.26; 288309-90-0; 24-hydroxycholesterol 7α-monooxygenase; CYP39A1; CYP39A1 oxysterol 7α-hydroxylase. Cat No: EXWM-0923.
24(R)-hydroxycholesterol
24(S)-Hydroxy cholesterol is a side-chain substituted oxysterol that is generated from the action of CYP46 on cholesterol found in the brain and plays an important role in cholesterol homeostasis. 24(R)-hydroxy Cholesterol is a synthetic enantiomer of 24(S)-hydroxy cholesterol that activates LXRα and LXRβ nuclear receptors with slightly reduced potency. Synonyms: (24R)-cholest-5-ene-3beta,24-diol; (3beta,24R)-Cholest-5-ene-3,24-diol. Grade: ≥98%. CAS No. 27460-26-0. Molecular formula: C27H46O2. Mole weight: 402.65.
24(R)-Hydroxycholesterol
24(R)-Hydroxycholesterol (24R-OHC) is a key intermediate of Tacalcitol (HY-32337) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 24R-OHC; 24R-HC; 24(R)-Cerebrosterol. CAS No. 27460-26-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-16940A.
25/26-hydroxycholesterol 7α-hydroxylase
A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Enzyme Commission Number: EC 1.14.14.29. CAS No. 149316-80-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0926; 25/26-hydroxycholesterol 7α-hydroxylase; EC 1.14.14.29; 149316-80-3; 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Cat No: EXWM-0926.
(3 β,24S)-Cholest-5-ene-3,24-diol
(3 β,24S)-Cholest-5-ene-3,24-diol. Group: Biochemicals. Alternative Names: Cholest-5-ene-3 β,24-diol; (24S)-24-Hydroxycholesterol; 24(S)-Hydroxycholesterol; 24-Hydroxycholesterol; 24S-Cholest-5-ene-3 β,24-diol; Cerebrosterin; Cerebrosterol; Cholest-5-ene-3 β,24 β-diol. Grades: Highly Purified. CAS No. 474-73-7. Pack Sizes: 1mg. Molecular Formula: C27H46O2, Molecular Weight: 402.65. US Biological Life Sciences.
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cholesterol 24-hydroxylase
A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood-brain barrier whereas cholesterol cannot. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Enzyme Commission Number: EC 1.14.14.25. CAS No. 50812-30-1, 213327-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0922; cholesterol 24-hydroxylase; EC 1.14.14.25; 50812-30-1, 213327-78-7; cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Cat No: EXWM-0922.
(1,1-Dimethylethyl)[[(3 β,25R)-ergosta-5,24(28)-dien-3-yl]oxy]dimethyl Silane is an intermediate in the synthesis of Ostreasterol which is a marine steroid, and also a derivative compound of hydroxycholesterol (H918040), which functions as the main cholesterol elimination product of the brain and was found to be increased in serum of Alzheimer patients. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg, 25mg. Molecular Formula: C34H60OSi. US Biological Life Sciences.
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