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| Product | Description | |
|---|---|---|
| Resatorvid | Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-? and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively. Resatorvid downregulates expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy and plays pivotal role in various inflammatory diseases[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAK-242; CLI-095. CAS No. 243984-11-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11109. |  |
| TLR4 Inhibitor, TAK-242 (Ethyl- (6R) -6- (N- (2-chloro-4-fluorophenyl) sulfamoyl) cyclohex-1-ene-1-carboxylate) | A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences. |  Worldwide |
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