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| Product | Description | |
|---|---|---|
| Resatorvid | Resatorvid is a small-molecule-specific inhibitor of TLR4 signaling. Synonyms: TAK-242; TAK 242; TAK242; Resatorvid; UNII-H2MZ648C31; ethyl (6R)-6-[(2-chloro-4-fluorophenyl)sulfamoyl]cyclohexene-1-carboxylate. Grades: > 95%. CAS No. 243984-11-4. Molecular formula: C15H17ClFNO4S. Mole weight: 361.82. |  |
| TLR4 Inhibitor, TAK-242 (Ethyl- (6R) -6- (N- (2-chloro-4-fluorophenyl) sulfamoyl) cyclohex-1-ene-1-carboxylate) | A cell-permeable cyclohexenecarboxylate that disrupts TLR4, but not TLR1-3 or TLR5-10, interaction with adaptor molecules TIRAP and TRAM via direct binding to TLR4 intracellular Cys747 residue.Shown to effectively inhibit TLR4-mediated cellular events (IC50 = 1.8, 1.3, and 1.9nM, respectively, against LPS-induced NO, IL-6, and TNF-alpha production in murine RAW264.7 macrophages) in vitro and completely prevent LPS- (7mg/kg, i.p.) induced death in mice (3mg/kg; i.v.) in vivo. Group: Biochemicals. Grades: Highly Purified. CAS No. 243984-11-4. Pack Sizes: 5mg. Molecular Formula: C??H??ClFNO?S, Primary Target: TLR4. US Biological Life Sciences. |  Worldwide |
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