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25-Hydroxycholesterol (25-OHC) is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC 50 ?65 nM) and selective suppressor of IgA production by B cells. Uses: Scientific research. Group: Natural products. Alternative Names: 25-OHC. CAS No. 2140-46-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113134.
25-Hydroxycholesterol-d 6 (25-OHC-d 6 ) is the deuterium labeled 25-Hydroxycholesterol. 25-Hydroxycholesterol is a metabolite of cholesterol that is produced and secreted by macrophages in response to Toll-like receptor (TLR) activation. 25-hydroxycholesterol is a potent (EC50?65 nM) and selective suppressor of IgA production by B cells[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: 25-OHC-d6. CAS No. 88247-69-2. Pack Sizes: 1 mg. Product ID: HY-113134S.
25/26-hydroxycholesterol 7α-hydroxylase
A P-450 (heme-thiolate) protein. Unlike EC 1.14.14.26, 24-hydroxycholesterol 7α-monooxygenase, which is specific for its oxysterol substrate, this enzyme can also metabolize the oxysterols 24,25-epoxycholesterol, 22-hydroxycholesterol and 24-hydroxycholesterol, but to a lesser extent. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Enzyme Commission Number: EC 1.14.14.29. CAS No. 149316-80-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0926; 25/26-hydroxycholesterol 7α-hydroxylase; EC 1.14.14.29; 149316-80-3; 25-hydroxycholesterol 7α-monooxygenase; CYP7B1; CYP7B1 oxysterol 7α-hydroxylase; 27-hydroxycholesterol 7-monooxygenase; 27-hydroxycholesterol 7α-hydroxylase; cholest-5-ene-3β,25-diol,NADPH:oxygen oxidoreductase (7α-hydroxylating); 25-hydroxycholesterol 7α-hydroxylase. Cat No: EXWM-0926.
25-Hydroxycholest-5-en-3beta-yl acetate
25-Hydroxycholest-5-en-3beta-yl acetate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 25-Hydroxycholesterol 3-acetate, MolPort-001-785-908, NSC226103, CID313018, 10525-22-1. Product Category: Heterocyclic Organic Compound. CAS No. 10525-22-1. Molecular formula: C29H48O3. Mole weight: 444.69 g/mol. Purity: 0.96. IUPACName: [17-(6-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate. Canonical SMILES: CC(CCCC(C)(C)O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC(=O)C)C)C. Density: 1.04g/cm³. ECNumber: 234-080-5. Product ID: ACM10525221. Alfa Chemistry ISO 9001:2015 Certified. Categories: EINECS 234-080-5.
25-Hydroxy Cholesterol
25-Hydroxy Cholesterol. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (3β)-Cholest-5-ene-3,25-diol. Appearance: White to Off-White Solid. CAS No. 2140-46-7. Molecular formula: C27H46O2. Mole weight: 402.65. Product ID: ACM2140467. Alfa Chemistry ISO 9001:2015 Certified. Categories: 25-Hydroxycholesterol.
25-Hydroxy-Cholesterol
25-hydroxycholesterol is an inhibitor of human immunodeficiency virus replication in vitro. It induces apoptosis in human monocytic cell lines as well as in CEM cells associated with negative regulation of c-Myc. Synonyms: (3β)-Cholest-5-ene-3,25-diol; Cholest-5-ene-3β,25-diol; 25-Hydroxy-5-cholestene-3β-ol; 5-Cholesten-3β,25-diol. Grades: >98%. CAS No. 2140-46-7. Molecular formula: C27H46O2. Mole weight: 402.65.
Intermediate in the preparation of 25-Hydroxycholesterol and derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 75861-02-8. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
cholesterol 24-hydroxylase
A P-450 heme-thiolate protein. The enzyme can also produce 25-hydroxycholesterol. In addition, it can further hydroxylate the product to 24,25-dihydroxycholesterol and 24,27-dihydroxycholesterol. This reaction is the first step in the enzymic degradation of cholesterol in the brain as hydroxycholesterol can pass the blood-brain barrier whereas cholesterol cannot. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase. Group: Enzymes. Synonyms: cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Enzyme Commission Number: EC 1.14.14.25. CAS No. 50812-30-1, 213327-78-7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0922; cholesterol 24-hydroxylase; EC 1.14.14.25; 50812-30-1, 213327-78-7; cholesterol 24-monooxygenase; CYP46; CYP46A1; cholesterol 24S-hydroxylase; cytochrome P450 46A1. Cat No: EXWM-0922.
SR3335
The retinoic acid receptor-related receptors (RORs) are orphan nuclear receptors with diverse putative roles. SR 3335 is a selective inverse agonist of RORα, competitively inhibiting the binding of 25-hydroxycholesterol to the ligand binding domain (Ki = 220 nM) and inhibiting constitutive transactivation activity (IC50 = 480 nM). It has no effect on RORβ, RORγ, farnesoid X receptor, or liver X receptor &alpha. SR 3335 evokes RORα-dependent effects both in vitro and in vivo, altering gene expression as well as gluconeogenesis. Synonyms: ML-176; SR 3335; SR-3335; ML176; ML 176. Grades: >98%. CAS No. 293753-05-6. Molecular formula: C13H9F6NO3S2. Mole weight: 405.34.
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