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| Product | Description | |
|---|---|---|
| CHIR-99021 | A potent and highly selective inhibitor of glycogen synthase kinase-3beta (GSK-3b) (IC50 = 6.7nM). CHIR99021 has been shown to allow for long-term expansion of murine embryonic stem cells in a chemically-defined medium in conjunction with MEK/MAPK inhibitor PD184352 and fibroblast growth factor receptor (FGFR) inhibitor SU5402. Group: Biochemicals. Alternative Names: 6-((2-((4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2- yl) pyrimidin-2-yl) amino) ethyl) amino) nicotinonitrile; CT99021; CHIR 911. Grades: Highly Purified. CAS No. 252917-06-9. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| CHIR-99021 | CHIR-99021 (CT99021) is a glycogen synthase kinase 3β (GSK3β) inhibitor that has antiproliferative activity in vitro and in vivo. It enhances reprogramming of mouse embryonic fibroblasts, transduced by Oct4 and Klf4 only, into iPSCs in combination with tranylcypromine. It also induces cardiomyocyte differentiation from human embryonic stem (ES). Uses: Potential antineoplastic agent. Synonyms: CHIR-99021; CT99021; 6-[2-[[4-(2,4-dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)pyrimidin-2-yl]amino]ethylamino]pyridine-3-carbonitrile. Grades: >98%. CAS No. 252917-06-9. Molecular formula: C22H18Cl2N8. Mole weight: 465.342. |  |
| Laduviglusib | Laduviglusib Inhibitor. Uses: Scientific use. Product Category: T2310. CAS No. 252917-06-9. |  |
| Laduviglusib (Standard) | Laduviglusib (Standard) is the analytical standard of Laduviglusib. Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC 50 s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-99021 (Standard); CT99021 (Standard). CAS No. 252917-06-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10182R. |  |
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