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| Product | Description | |
|---|---|---|
| Gambogic acid | Gambogic acid is a natural product inhibitor of Hsp90. Synonyms: B-Guttiferrin; Beta-Guttiferrin; Beta-Guttilactone; Cambogic acid; Guttatic acid; Guttic acid. Grades: >95%. CAS No. 2752-65-0. Molecular formula: C38H44O8. Mole weight: 628.76. |  |
| Gambogic Acid | Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM. Group: Inhibitors. Alternative Names: β-Guttilactone. CAS No. 2752-65-0. Molecular formula: C38H44O8. Mole weight: 628.75. Appearance: Yellow powder. Purity: 0.98. IUPACName: (Z)-4-[(1S, 2S, 8R, 17S, 19R)-12-hydroxy-8, 21, 21-trimethyl-5-(3-methylbut-2-enyl)-8-(4-methylpent-3-enyl)-14, 18-dioxo-3, 7, 20-trioxahexacyclo[15.4.1.02, 15.02, 19.04, 13.06, 11]docosa-4(13), 5, 9, 11, 15-pentaen-19-yl]-2-methylbut-2-enoic acid. Canonical SMILES: CC (=CCC[C@@]1 (C=CC2=C (C3=C (C (=C2O1)CC=C (C)C)O[C@@]45[C@H]6C[C@@H] (C=C4C3=O)C (=O)[C@@]5 (OC6 (C)C)C/C=C (/C)\C (=O)O)O)C)C. Density: 1.11 g/ml. Catalog: ACM2752650. |  |
| Gambogic Acid | Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-X L , Bcl-2 , Bcl-W , Bcl-B , Bfl-1 and Mcl-1 with IC 50 s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Beta-Guttiferrin. CAS No. 2752-65-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-N0087. |  |
| Gambogic Acid | Gambogic Acid is an apoptosis inducer in sever tumor cell lines via regulation of Bax and inhibition of Bcl-2 genes. Induces EGFR degredation through AMPK dependant-LRIG1 upregulation in glioma cells. Apoptosis inducer in several tumor cell lines including T47D cells. Activates caspases (EC50 values are 0.78 - 1.64uM) and competitively inhibits antiapoptotic Bcl-2 family proteins (IC50 values are 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79uM for Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 respectively). Reverses gefitinib-resistance in mice bearing tumors with EGFR-T790M mutation. Also blocks Kir2.1 channels (EC50 ≤100nM). Group: Biochemicals. Alternative Names: (2Z)-2-Methyl-4-[(1R,3aS,5S,11R,14aS)-3a,4,5,7-tetrahydro-8-hydroxy-3,3,11-trimethyl-13-(3-methyl-2-butenyl)-11-(4-methyl-3-pentenyl)-7,15-dioxo-1,5-methano-1H,3H,11H-furo[3,4-g]pyrano[3,2-b]xanthen-1-yl]-2-butenoic acid. Grades: Purified. CAS No. 2752-65-0. Pack Sizes: 10mg, 50mg. Molecular Formula: C38H44O8, Molecular Weight: 628.75. US Biological Life Sciences. |  Worldwide |
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