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HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HOOBt. CAS No. 28230-32-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-Y0493.
HODHBt
HOOBt is a STAT5-SUMO protein-protein interaction inhibitor that suppresses SUMOylation of phosphorylated STAT5. Synonyms: 28230-32-2; 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one; HOOBT; HODHBT; 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; 3-hydroxy-1,2,3-benzotriazin-4-one; 3-Hydroxy-1,2,3-ben zotriazin-4(3H)-one; 1,2,3-Benzotriazin-4(3H)-one, 3-hydroxy-; Z5000NB5EL; 3-HYDROXYBENZO[D][1,2,3]TRIAZIN-4(3H)-ONE; NSC-279266; 3-HYDROXY-3,4-DIHYDRO-1,2,3-BENZOTRIAZIN-4-ONE; 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazine; E. Grade: 98% (HPLC). CAS No. 28230-32-2. Molecular formula: C23H27N3O5. Mole weight: 425.5.
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