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HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HOOBt. CAS No. 28230-32-2. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-Y0493.
HOOBT
HOOBt is a STAT5-SUMO protein-protein interaction inhibitor that suppresses SUMOylation of phosphorylated STAT5. Synonyms: 3-Hydroxy-1,2,3-benzotriazin-4(3H)-one; 3-hydroxy-3H-benzo[d][1,2,3]triazin-4-one; DHBT; oxohydroxybenzotriazole; 4-oxo-3,4-dihydro-3-hydroxy-1,2,3-benzotriazine; 3-Hydroxy-4-ketobenzotriazine; 3,4-Dihydro-3-hydroxy-4-oxo-1,2,3-benzotriazine; 1,2,3-Benzotriazin-4(3H)-one,3-hydroxy; 3,4-dihydro-3-hydroxy-4-keto-1,2,3-benzotriazine; 3-Hydroxy-3,4-dihydro-4-oxo-1,2,3-benzotriazine. Grades: 98% (HPLC). CAS No. 28230-32-2. Molecular formula: C7H5N3O2. Mole weight: 163.13.
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