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| Product | Description | |
|---|---|---|
| Nigericin | 5mg Pack Size. Group: Antibiotics, Bioactive Small Molecules. Formula: C40H67NaO11. CAS No. 28380-24-7. Prepack ID 50435888-5mg. Molecular Weight 746.94. See USA prepack pricing. |  |
| Nigericin | Nigericin, derived from S. hygroscopicus, is an antibiotic potassium ionophore. It exchanges K+ for H+ across biological membranes. Nigericin can be a NLRP3 activator that induces the release of IL-1β as a NALP3-dependent manner. Nigericin triggers eryptosis, an effect paralleled by ROS formation, and in part due to induction of oxidative stress. Nigericin triggers apoptosis. Synonyms: 2-[6-[[2-[5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyloxan-2-yl]-3-methyloxolan-2-yl]-5-methyloxolan-2-yl]-7-methoxy-2,4,6-trimethyl-1,10-dioxaspiro[4.5]decan-9-yl]methyl]-3-methyloxan-2-yl]propanoic acid; Antibiotic K178; Antibiotic X464; Azalomycin M; Helexin C, Polyetherin A. Grades: >98%. CAS No. 28380-24-7. Molecular formula: C40H68O11. Mole weight: 724.96. |  |
| Nigericin | Nigericin is an antibiotic derived from Streptomyces hygroscopicus that act as a K + /H + ionophore , promoting K + /H + exchange across mitochondrial membranes. Nigericin is a NLRP3 activator. Nigericin shows promising anti-cancer activities through decreasing intracellular pH (pHi), and inactivation of Wnt / β-catenin signals. Nigericin induces pyroptosis through caspase 1 /GSDMD in TNBC [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 28380-24-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-127019. |  |
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