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| Product | Description | |
|---|---|---|
| XAV939 | XAV 939 is a tankyrase (TNKS) inhibitor with IC50 values of 11 nM and 4 nM for tankyrase 1 and 2 respectively. XAV 939 antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. It also suppresses proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Uses: Differentiation. Synonyms: XAV939; XAV 939; XAV-939. 3,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one. Grades: 0.98. CAS No. 284028-89-3. Molecular formula: C14H11F3N2OS. Mole weight: 312.31. |  |
| XAV 939 | A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1. Group: Biochemicals. Alternative Names: 1, 5, 7, 8-Tetrahydro-2-[4- (trifluoromethyl) phenyl]-4H-thiopyrano[4, 3-d]pyrimidin-4-one; NVP-XAV 939. Grades: Highly Purified. CAS No. 284028-89-3. Pack Sizes: 25mg. US Biological Life Sciences. |  Worldwide |
| XAV-939 | XAV-939 Inhibitor. Uses: Scientific use. Product Category: T1878. CAS No. 284028-89-3. |  |
| XAV-939 | XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC 50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 284028-89-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-15147. |  |
| XAV939 (3, 5, 7, 8-Tetrahydro-2-[4- (trifluoromethyl) phenyl]-4H-thiopyrano[4, 3-d]pyrimidin-4-one) | A Tankyrase (TNKS) inhibitor (IC50 = 110nM for TNKS1 and 4nM for TNKS2). Antagonizes wnt signaling via stimulation of beta-catenin degradation and stabilization of axin. Inhibits proliferation of the mu-catenin-dependent colon carcinoma cell line DLD-1. Group: Biochemicals. Alternative Names: 3, 5, 7, 8-Tetrahydro-2-[4- (trifluoromethyl) phenyl]-4H-thi opyrano[4,3-d]pyrimidin-4-one. Grades: Highly Purified. CAS No. 284028-89-3. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
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