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| Product | Description | |
|---|---|---|
| Netupitant | Netupitant (CID-6451149) is a highly potent, selective and orally active neurokinin-1 (NK 1 ) receptor antagonist with a K i of 0.95 nM for hNK 1 in CHO cells. Netupitant has antiemetic affect [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID 6451149. CAS No. 290297-26-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-16346. |  |
| Netupitant | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. Synonyms: AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant. Grades: >98%. CAS No. 290297-26-6. Molecular formula: C30H32F6N4O. Mole weight: 578.603. |  |
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