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Netupitant Quick inquiry Where to buy Suppliers range | Netupitant is a selective neurokinin 1 (NK1) receptor antagonist with potential antiemetic activity. Netupitant competitively binds to and blocks the human substance P/NK1 receptors in the central nervous system (CNS), thereby inhibiting NK1-receptor binding of the endogenous tachykinin neuropeptide substance P (SP), which may result in the prevention of chemotherapy-induced nausea and vomiting (CINV). SP is found in neurons of vagal afferent fibers innervating the brain-stem nucleus tractus solitarii and the area postrema, which contains the chemoreceptor trigger zone (CTZ), and may be elevated in response to chemotherapy. The NK-receptor is a G-protein receptor coupled to the inositol phosphate signal-transduction pathway and is found in both the nucleus tractus solitarii and the area postrema. On 10/10 2014 FDA approved netupitant for the treatment of nausea and vomiting in patients undergoing cancer chemotherapy. Synonyms: AGE94200; AGE-94200; AGE 94200;Ro 67-3189; Ro-67-3189; Ro67-3189; CHEBI441603; CID6451149; D05152; UNII-7732P08TIR, CHEMBL206253, AG-E-94200, Netupitant. Grades: >98%. CAS No. 290297-26-6. Molecular formula: C30H32F6N4O. Mole weight: 578.603. | |
Netupitant Quick inquiry Where to buy Suppliers range | Netupitant. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 290297-26-6. IUPAC Name: 2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethyl-N-[4-(2-methylphenyl)-6-(4-methylpiperazin-1-yl)pyridin-3-yl]propanamide. Molecular formula: C30H32F6N4O. Mole weight: 578.59. Catalog: APS290297266. SMILES: CN (C (=O)C (C) (C)c1cc (cc (c1)C (F) (F)F)C (F) (F)F)c2cnc (cc2c3ccccc3C)N4CCN (C)CC4. Format: Neat. | |
Netupitant Quick inquiry Where to buy Suppliers range | Netupitant. CAS No. 290297-26-6. |