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| Product | Description | |
|---|---|---|
| 3-(4-Methoxyphenyl)-1H-pyrazole-5-carbohydrazide | 3-(4-Methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g, 2g, 5g, 10g, 25g. US Biological Life Sciences. |  Worldwide |
| 3-(4-Methoxyphenyl)-1H-pyrazole-5-carbohydrazide 98+% (HPLC) | 3-(4-Methoxyphenyl)-1H-pyrazole-5-carbohydrazide 98+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 1g, 5g, 25g. US Biological Life Sciences. | Worldwide |
| Sphingosine Kinase 1 Inhibitor, SKI-178 (N'- (1E) -1- (3, 4-Dimethoxyphenyl) ethylidene) -3- (4-methoxyphenyl) -1H-pyrazole-5-carbohydrazide, Dimethoxyphenyl-ethylidene-methoxyphenyl-pyrazole-carbohydrazide) | A cell-permeable pyrazolocarbohydrazide compound that acts as a potent, reversible, sphingosine competitive and ATP-non-competitive inhibitor of sphingosine kinase 1 (SphK1) activity with excellent selectivity over SphK2 (Ki = 1.33 and >> 25uM, respectively). Shown to suppress sphingosine-1-phosphate (S1P) production in A549 cells and efficiently induce apoptosis in several tumor cells (IC50 in the range of 0.1-1.8uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| SKI 178 | SKI 178 is a non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM) used for the treatment of AML. SKI 178 has been shown to induce CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Uses: Aml treatment. Synonyms: SKI-178; SKI 178; SKI178. N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Grades: ≥98% by HPLC. CAS No. 1259484-97-3. Molecular formula: C21H22N4O4. Mole weight: 394.42. |  |
| SKI-178 | SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). SKI-178 induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. SKI-178 is a novel therapeutic agent for the treatment of AML, including multidrug-resistant/recurrent AML subtypes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKI-178; SKI 178; SKI178. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1259484-97-3. Molecular formula: C21H22N4O4. Mole weight: 394.43. Purity: >98%. IUPACName: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Canonical SMILES: O=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C. Product ID: ACM1259484973. Alfa Chemistry ISO 9001:2015 Certified. |  |
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