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4-Fluoro-3-chloroaniline, is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds such as, novel 6-Fluorobenzothiazole-substituted pyrazole analogues, having antiinflammatory activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-Chloro-4-fluorobenzenamine;CHLOROFLUOROANILINE;para-fluoro-meta-chloroaniline;Benzenamine,3-chloro-4-fluoro;4-fluoro-3-chloro-aniline. Product Category: Aryl Fluorinated Building Blocks. Appearance: White crystalline powder. CAS No. 367-21-5. Molecular formula: C6H5ClFN. Mole weight: 145.56. Density: 1.226 g/cm³. Product ID: ACM367215. Alfa Chemistry ISO 9001:2015 Certified.
3-Chloro-4-fluoroaniline
Gefitinib Impurity V is an organic Fluorinated building block used for the synthesis of pharmaceutical and biologically active compounds. It has antiinflammatory activity. Synonyms: 3-chloro-4-fluoroaniline. Grades: > 95 %. CAS No. 367-21-5. Molecular formula: C6H5ClFN. Mole weight: 145.56.
3-Chloro-4-fluoroaniline 99+%
3-Chloro-4-fluoroaniline 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 367-21-5. Pack Sizes: 100g, 250g, 25g, 1Kg, 5Kg. US Biological Life Sciences.
Worldwide
4-Fluoro-3-chloroaniline
4-Fluoro-3-chloroaniline. Group: Biochemicals. Alternative Names: 3-Chloro-4-fluorobenzenamine; 3-Chloro-4-fluoroaniline; 3-Chloro-4-fluorobenzenamine; 3-Chloro-4-fluorophenylamine; NSC 10290; m-Chloro-p-fluoroaniline. Grades: Highly Purified. CAS No. 367-21-5. Pack Sizes: 10g. Molecular Formula: C6H5ClFN, Molecular Weight: 145.56. US Biological Life Sciences.
Intermediate in the preparation of Tyrosine Kinase Inhibitors. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-6-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-7-ethoxy-3-quinolinecarbonitrile. Grades: Highly Purified. CAS No. 915945-40-3. Pack Sizes: 25mg. US Biological Life Sciences.
Pelitinib intermediate. Group: Biochemicals. Alternative Names: 4-[(3-Chloro-4-fluorophenyl)amino]-7-ethoxy-6-nitro-3-quinolinecarbonitrile. Grades: Highly Purified. CAS No. 740791-06-4. Pack Sizes: 50mg. US Biological Life Sciences.
Intermediate in the preparation of Tyrosine Kinase Inhibitors. Group: Biochemicals. Alternative Names: 6-Amino-4-[(3-chloro-4-fluorophenyl)amino]-7-ethoxy-3-quinolinecarbonitrile; 6-Amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxy-quinoline-3-carbonitrile. Grades: Highly Purified. CAS No. 361162-95-0. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Afatinib Impurity O
An impurity of Afatinib, a medication used to treat non-small cell lung carcinoma (NSCLC). Synonyms: (S,E)-4-broMo-N-(4-((3-chloro-4-fluorophenyl)aMino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enaMide; (E)-4-bromo-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]but-2-enamide; Bromo-Afatinib; C22H19BrClFN4O3; AFATINIB IMPURITY O; SCHEMBL16398947; SCHEMBL16398952; IQJWAIKYBNTYPG-YUKKFKLSSA-N; CS-0164267; (2E)-4-Bromo-N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3S)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-2-butenamide; (S,E)-4-Bromo-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)but-2-enamide (Afatinib Impurity). Grades: ≥95%. Molecular formula: C18H15FN4O4. Mole weight: 370.34.
AV-412
AV-412 is a second-generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR/HER2 inhibitor AV-412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may suppress tumor growth and angiogenesis, and tumor regression in EGFR/HER2-expressing tumors. This agent may be active against EGFR/HER2-expressing tumor cells that are resistant to first-generation kinase inhibitors. EGFR and HER2 are receptor tyrosine kinases that play major roles in tumor cell proliferation and tumor vascularization. Synonyms: AV 412; AV412; N-[4-(3-chloro-4-fluoroanilino)-7-[3-methyl-3-(4-methylpiperazin-1-yl)but-1-ynyl]quinazolin-6-yl]prop-2-enamide. CAS No. 451492-95-8. Molecular formula: C27H28ClFN6O. Mole weight: 507.01.
Canertinib
Canertinib (CI-1033;PD-183805) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. Canertinib is active against vaccinia virus respiratory infection in mice. Uses: Designed for use in research and industrial production. Additional or Alternative Names: N-[4-(3-Chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide. Product Category: Inhibitors. CAS No. 267243-28-7. Mole weight: 485.9. Purity: 95%+. Product ID: ACM267243287. Alfa Chemistry ISO 9001:2015 Certified.