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| Product | Description | |
|---|---|---|
| SB431542 | SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. Uses: Reprogramming, differentiation. Synonyms: SB431542; SB-431542; SB 431542. Grades: 98%. CAS No. 301836-41-9. Molecular formula: C22H16N4O3. Mole weight: 384.39. |  |
| SB 431542 | SB 431542 is a potent and selective inhibitor of the TGF- β1 receptor ALK5 (IC50 = 94 nM)1. It inhibits ALK4 only at higher concentrations (IC50 = 140nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM)2 and ALK7.3 It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested.3 SB 431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer.3 Through its effects on ALK/Smad signaling, SB 431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.4,5. Group: Biochemicals. Alternative Names: 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide. Grades: Highly Purified. CAS No. 301836-41-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| SB-431542 | SB-431542 Inhibitor. Uses: Scientific use. Product Category: T1726. CAS No. 301836-41-9. |  |
| SB-431542 | SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10431. |  |
| SB-431542 (Standard) | SB-431542 (Standard) is the analytical standard of SB-431542. SB-431542 is a TGF-β receptor kinase inhibitor (TRKI). SB-431542 has inhibitory activity for ALK4, ALK5 and ALK7 with IC 50 values of 1 μM, 0.75 μM and 2 μM, respectively. SB-431542 also inhibits TGF-β-induced transcription, gene expression, apoptosis, and growth suppression. SB-431542 can be used for the research of cancer and signal transduction pathways [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 301836-41-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-10431R. | |
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