30195 30 3 Suppliers USA
Find where to buy products from suppliers in the USA, including: distributors, industrial manufacturers in America, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the American suppliers website for prices, SDS or more information. You can also view suppliers in Australia, NZ or the UK.
Product | Description | |
---|---|---|
CBF beta-Runx1 Inhibitor II, Ro5-3335 ([7-chloro-5-(2-pyrryl)-3H-1,4 benzodiazapin-2-(H)-one], Ro53335, CBFalpha-CBFbeta Inhibitor II) Quick inquiry Where to buy Suppliers range | A cell-permeable benzodiazepine that suppresses CBFalpha/Runx1-CBFbeta transactivation activity (25uM; 293-0 cells) via direct bindings to both subunits of the heterodimeric transcription factor complex. Shown to inhibit oncogenic fusion CBFB-MYH11-, TEL-RUNX1-, and RUNX1-ETO-, dependent leukemia cells proliferation (IC50 = 1.1 to 21.7uM) in vitro and more effectively reduce peripheral blood c-kit+ population (300mg/kg/d via animal feed) than Cytarabine in a murine Cbfb-MYH11 leukemia model in vivo. Comparing to CBFbeta-Runx1 Inhibitor I, Ro5-3335 modulates the Runx1-CBFbeta heterodimer formation without completely disrupting the subunits interaction. Group: Biochemicals. Grades: Highly Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Ro 5-3335 Quick inquiry Where to buy Suppliers range | Ro 5-3335, a benzodiazepine, is a core binding factor (CBF) leukemia inhibitor. It is highly active in vitro (IC50 = 0.1-1.0 microM [corrected]) against HIV-1 viruses of AIDS resistant or non-resistant to zidovudine (AZT). Synonyms: Ro 5-3335; Ro-5-3335; Ro 5 3335; 7-Chloro-1,3-dihydro-5-(1H-pyrrol-2-yl)-2H-1,4-benzodiazepin-2-one; 2H-1,4-Benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-pyrrol-2-yl- (7CI,8CI); NSC 66020; NSC66020; NSC-66020. Grades: ≥98% by HPLC. CAS No. 30195-30-3. Molecular formula: C13H10ClN3O. Mole weight: 259.69. | |
Ro 5-3335 Quick inquiry Where to buy Suppliers range | Ro 5-3335. Group: Biochemicals. Grades: Purified. CAS No. 30195-30-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Ro5-3335 Quick inquiry Where to buy Suppliers range | Ro5-3335 Inhibitor. Uses: Scientific use. Product Category: T4687. CAS No. 30195-30-3. |