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| Product | Description | |
|---|---|---|
| 3-Keto-N-aminoethyl-N-aminocaproyldi hydrocinnamoyl Cyclopamine (KAAD-Cyclopamine) | Cyclopamine demonstrates teratogenic properties and has been shown to reverse effects of oncogenic mutations in Smoothened and sonic hedgehog intracellular signaling. The KAAD derivative has shown 10-20 fold higher potency than cyclopamine in inhibition of beta-Galactosidase expression in Ptch(-/-) cells. Group: Biochemicals. Alternative Names: KAAD-Cyclopamine. Grades: Highly Purified. CAS No. 306387-90-6. Pack Sizes: 250ug. US Biological Life Sciences. |  Worldwide |
| Cyclopamine-KAAD (3-Keto-N-aminoethyl-aminocaproyldi hydrocinnamoyl cyclopamine, Shh Signaling Antagonist II) | A potent, cell-permeable analog of Cyclopamine that specifically inhibits the Hedgehog (Hh) signaling with similar or lower toxicity (IC50 = 20nM in Shh-LIGHT2 assay; 50nM in p2Ptch-/-cells; 500nM in SmoA1-LIGHT cells). Binds to SmoA1 and promotes its exit from the endoplasmic reticulum. Suppresses both the ShhNp-induced pathway activity and SmoA1-induced reporter activity. Shown to sensitize human glioma cells to TRAIL-induced apoptosis. Group: Biochemicals. Grades: Purified. CAS No. 306387-90-6. Pack Sizes: 100ug. Molecular Formula: C??H??N?O?, Primary Target: Hh signaling in Shh-light2 assay. US Biological Life Sciences. | Worldwide |
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