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| Product | Description | |
|---|---|---|
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione | 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione. Group: Biochemicals. Alternative Names: GSK-3b inhibitor I, TDZD-8. Grades: Highly Purified. CAS No. 327036-89-5. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C10H10N2O2S. US Biological Life Sciences. |  Worldwide |
| 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione (GSK-3ß Inhibitor I, TDZD-8) | Glycogen Synthase Kinase-3ß is a highly conserved ubiquitously expressed serine/threonine protein kinase involved in signal transduction cascades of multiple cellular processes. 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione, also known as TDZD-8, is a thiadiazolidinone (TDZD) analogue that acts as a highly selective, non-ATP competitive inhibitor of GSK3b (IC50 =2nM). It binds to the active site of GSK3b. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, PKA, and PKC (IC50 >100nM). Group: Biochemicals. Alternative Names: GSK-3ß Inhibitor I, TDZD-8. Grades: Highly Purified. CAS No. 327036-89-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TDZD-8 | TDZD-8 is a derivative of thiadiazolidine (TDZD) and acts as a non-ATP competitive inhibitor of GSK3&beta. It was shown to inhibit proliferation and self-renewal of glioblastoma stem cells. Synonyms: 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione; GSK-3beta Inhibitor I; TDZD 8; 1,2,4-Thiadiazolidine-3,5-dione, 2-methyl-4-(phenylmethyl)-. Grades: >98%. CAS No. 327036-89-5. Molecular formula: C10H10N2O2S. Mole weight: 222.262. |  |
| TDZD-8 | TDZD-8 is an inhibitor of GSK-3β , with an IC 50 of 2 μM; TDZD-8 shows less potent activities against Cdk-1/cyclin?B, CK-II, PKA, and PKC, with all IC 50 s of >100 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK-3β Inhibitor I; NP 01139. CAS No. 327036-89-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-11012. |  |
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