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| Product | Description | |
|---|---|---|
| C646 | C646 is an inhibitor for histone acetyltransferase, and inhibits p300 with a Ki of 400 nM. Preferentially selective for p300 versus other acetyltransferases. Synonyms: C646; C-646; C 646. Grades: >98%. CAS No. 328968-36-1. Molecular formula: C24H19N3O6. Mole weight: 445.42. |  |
| C646 | Reversible cell permeable p300/CBP histone acetyltransferase (HAT) inhibitor. Specific inhibition to p300 (86%) compared to N-acetyltransferase, PCAF, GCN5, Rtt109, Sas or MOZ histone acetyltransferases (<10%). Cell growth inhibitor in melanoma and non-small-cell-lung (NSCL) human cancer cell lines. Group: Biochemicals. Alternative Names: (E)-4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)-methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid. Grades: Highly Purified. CAS No. 328968-36-1. Pack Sizes: 1mg, 5mg. Molecular Formula: C24H19N3O6. US Biological Life Sciences. |  Worldwide |
| C 646 | C 646. Group: Biochemicals. Grades: Purified. CAS No. 328968-36-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| C-646, HAT Inhibitor (4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid) | Potent and selective inhibitor of the histone acetyl transferase p300/CBP (Ki=400 nM ). Induces apoptosis in prostate cancer cells. Enhances fear extinction memory and synaptic plasticity in mice. Promotes tau deacetylation reducing levels of pathogenic p-tau. Cell permeable. Group: Biochemicals. Alternative Names: 4-[4-[[5-(4,5-Dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1Hpyrazol- 1-yl]benzoic acid. Grades: Highly Purified. CAS No. 328968-36-1. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
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