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| Product | Description | |
|---|---|---|
| Aurora Kinase Inhibitor VI, ZM447439 (4-(4-(N-Benzoylamino)anilino)-6- methoxy-7- (3- (1-morpholino) propoxy) quinazoline) | A cell-permeable quinazoline compound that targets the ATP binding pocket and an adjacent cleft and acts as a potent and reversible inhibitor of Aurora A and Aurora B (IC50=110 and 130nM, respectively) with moderate to excellent selectivity among closely related 16-kinase panel (IC50=0.88, 1.03 and 1.79uM for Lck, Src and MEK1, respectively, and IC50>10uM for Cdk1/2/4, Plk1, Chk1). Blocks phosphorylation of Histone H3-Ser10 in Xenopus cycling egg extracts at 20uM, and reduces mitotic spindle assembly. Shown to repress kinetochore localization of BubR1, Cenp-E, and Mad2, and arrest the growth of proliferating tumor cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 331771-20-1. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| N- [4- [ [6-Methoxy-7- [3- (4-morpholinyl) propoxy] -4-quinazolinyl] amino] phenyl] benzamide | N- [4- [ [6-Methoxy-7- [3- (4-morpholinyl) propoxy] -4-quinazolinyl] amino] phenyl] benzamide. Group: Biochemicals. Grades: Highly Purified. CAS No. 331771-20-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C29H31O4N5. US Biological Life Sciences. | Worldwide |
| ZM447439 | ZM 447439 is a selective and ATP-competitive inhibitor for Aurora A and Aurora B with IC50 of 110 nM, 130 nM respectively, > 8 fold selectivity than Aurora C. Synonyms: Code name: ZM447439; ZM-447439; ZM 447439. Grades: 0.98. CAS No. 331771-20-1. Molecular formula: C29H31N5O4. Mole weight: 513.59. |  |
| ZM 447439 | It is a potent and selective inhibitor of Aurora B kinase. Cells treated with ZM-447439 progress through interphase, enter mitosis and assemble bipolar spindles but chromosome alignment, segregation and cytokinesis all fail. It induces apoptosos in Hep2 cancer cells and in acute myeloid leukemia cell lines but its propensity to induce polyploidy does not inevitably result in apoptosis. Group: Biochemicals. Alternative Names: N- [4- [ [6-Methoxy-7- [3- (4-morpholinyl) propoxy] -4-quinazolinyl] amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 331771-20-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ZM-447439 | ZM-447439 is an aurora kinase inhibitor with IC 50 s of 110 and 130 nM for aurora A and B, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 331771-20-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10128. |  |
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