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| Product | Description | |
|---|---|---|
| API-2 | API-2. Group: Biochemicals. Grades: Purified. CAS No. 35943-35-2. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Tricirbine | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Synonyms: VQD-002; VQD 002; VQD002; NSC-154020; NSC 154020; NSC154020; Triciribine; TCN-P; triciribine; Tricyclic nucleoside; Pentaazacentopthylene; API-2; Akt Inhibitor V. Grades: 99.81%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.309. |  |
| Triciribine | Cell-permeable. A synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. Group: Biochemicals. Alternative Names: 1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,2,5,6,8-pentaazanaphthylen-3-amine, NSC 154020. Grades: Highly Purified. CAS No. 35943-35-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Triciribine | Triciribine is a DNA synthesis inhibitor, also inhibits Akt and HIV-1/2 with IC 50 of 130 nM, and 0.02-0.46 μM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: API-2; NSC 154020; TCN. CAS No. 35943-35-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15457. |  |
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