35943 35 2 Suppliers USA
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Product | Description | |
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API-2 Quick inquiry Where to buy Suppliers range | API-2. Group: Biochemicals. Grades: Purified. CAS No. 35943-35-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
Tricirbine Quick inquiry Where to buy Suppliers range | Triciribine is a potent AKT inhibitor and a cell-permeable tricyclic nucleoside molecule with potential antineoplastic activity. Akt-1, -2, and -3 are serine/threonine protein kinases in the phosphatidylinositol (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival. Following recruitment of Akt to the plasma membrane, phosphorylation at threonine 308 and serine 473 (Akt-1 numbering) by phosphoinositide-dependent kinases (PDK) 1 and 2 results in full activation of the enzyme. Triciribine is a cell-permeable tricyclic nucleoside that inhibits the phosphorylation, activation, and signalling of Akt-1, -2, and -3. It does not inhibit phosphatidylinositol 3 (PI3)-Kinase or PDK1, the direct upstream activators of Akt, nor does it inhibit PKC, PKA, ERK1/2, serum- and glucocorticoid-inducible kinase, p38, STAT3, or JNK signalling pathways. Triciribine effectively inhibits growth of Akt-overexpressing human cancer cell lines in vitro with 50% inhibition at ~5-10 μM. It also inhibit growth of tumor xenografts in mice by greater than 80% at a dose of 1 mg/kg/day. Synonyms: VQD-002; VQD 002; VQD002; NSC-154020; NSC 154020; NSC154020; Triciribine; TCN-P; triciribine; Tricyclic nucleoside; Pentaazacentopthylene; API-2; Akt Inhibitor V. Grades: 99.81%. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.309. | |
Triciribine Quick inquiry Where to buy Suppliers range | Cell-permeable. A synthetic tricyclic nucleoside which acts as a specific inhibitor of the Akt signaling pathway. It selectively inhibits the phosphorylation and activation of Akt1, -2 and -3 but does not inhibit Akt kinase activity nor known upstream Akt activators such as PI 3-Kinase and PDK1. Group: Biochemicals. Alternative Names: 1,5-Dihydro-5-methyl-1-b-D-ribofuranosyl-1,2,5,6,8-pentaazanaphthylen-3-amine, NSC 154020. Grades: Highly Purified. CAS No. 35943-35-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
Triciribine Quick inquiry Where to buy Suppliers range | Triciribine. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 35943-35-2. Molecular formula: C13H16N6O4. Mole weight: 320.30. Catalog: APS35943352. SMILES: CN1N=C (N)c2cn ([C@@H]3O[C@H] (CO)[C@@H] (O)[C@H]3O)c4ncnc1c24. Format: Neat. | |
Triciribine Quick inquiry Where to buy Suppliers range | Triciribine. CAS No. 35943-35-2. | |
Triciribine hydrate Quick inquiry Where to buy Suppliers range | ≥97% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 35943-35-2 (anhydrous). Pack Sizes: 5MG, 25MG. Mole weight: 320.30 (anhydrous basis). Catalog: ALP35943352. Assay: ≥97% (HPLC). |