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| Product | Description | |
|---|---|---|
| 2-Methyl-(3,4,6-tri-O-acetyl-1,2-dideoxy-a-D-glucopyrano)-[2,1-d]-2-oxazoline | A novel inhibitor of the HBP enzyme PGM3 with effect against breast cancer. FR054 suppresses cancer growth in MDA-MB-231 xenograft mice. Synonyms: FR054; FR 054; FR-054. CAS No. 35954-65-5. Molecular formula: C14H19NO8. Mole weight: 329.31. |  |
| 6R-FR054 | 6R-FR054 is a 6R-isomer of FR054. FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. In particular, in a model of Triple Negative Breast Cancer (TNBC) cells, MDA-MB-231, these effects are correlated to FR054-dependent reduction of both N- and O-glycosylation level that cause also a strong reduction of cancer cell adhesion and migration. Note: The correct structure for FR054 is CAS#35954-65-5 which is the 6S-isomer. Some vendors are selling wrong structure for FAR054 (the incorrect structure has CAS#10378-06-0, which is the 6R-isomer). Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6R-FR054; 6R-FR-054; 6R-FR 054. Product Category: Inhibitors. Appearance: Semi-solid or waxy solid or viscous solid. CAS No. 10378-06-0. Molecular formula: C14H19NO8. Mole weight: 329.31. Purity: >98%. IUPACName: 5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, diacetate (ester), (3aR,5R,6R,7R,7aR)-. Canonical SMILES: CC1=N[C@@]([C@@H](OC(C)=O)[C@@H](OC(C)=O)[C@@H](COC(C)=O)O2)([H])[C@@]2([H])O1. Product ID: ACM10378060. Alfa Chemistry ISO 9001:2015 Certified. Categories: (6R)-FR054. |  |
| FR054 | FR054 is an inhibitor of the Hexosamine Biosynthetic Pathway (HBP) enzyme PGM3, with a remarkable anti-breast cancer effect. FR054 induces in different breast cancer cells a dramatic decrease in cell proliferation and survival. In particular, in a model of Triple Negative Breast Cancer (TNBC) cells, MDA-MB-231, these effects are correlated to FR054-dependent reduction of both N- and O-glycosylation level that cause also a strong reduction of cancer cell adhesion and migration. Note: The correct structure for FR054 is CAS#35954-65-5 which is the 6S-isomer. Some vendors are selling wrong structure for FAR054 (the incorrect structure has CAS#10378-06-0, which is the 6R-isomer). Note this product is being supplied as ethanol solution at 100mg/mL. Uses: Designed for use in research and industrial production. Additional or Alternative Names: FR054; FR-054; FR 054. Product Category: Inhibitors. Appearance: Viscouse waxy semi-solid. CAS No. 35954-65-5. Molecular formula: C14H19NO8. Mole weight: 329.31. Purity: >98%. IUPACName: 5H-Pyrano[3,2-d]oxazole-6,7-diol, 5-[(acetyloxy)methyl]-3a,6,7,7a-tetrahydro-2-methyl-, diacetate (ester), (3aR,5R,6S,7R,7aR)-. Canonical SMILES: CC1=N[C@@]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O2)([H])[C@@]2([H])O1. Product ID: ACM35954655-1. Alfa Chemistry ISO 9001:2015 Certified. | |
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