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| Product | Description | |
|---|---|---|
| LY 364947 | Selective inhibitor of TGF- β type-I receptor (TGF- β RI, TGFR-I, T βR-I, ALK-5) (IC50 values are 59, 400 and 1400nM for TGR- β RI, TGF- β RII and MLK-7K respectively). Inhibits TGF- β-dependent luciferase production in mink lung cells (p3TP lux) and growth in mouse fibroblasts (NIH 3T3) (IC50 values are 47 and 89nM respectively). Suppresses invasion of MDA-MB-231 breast cancer cells in a matrigel invasion assay. Group: Biochemicals. Alternative Names: 4-[3-(2-pyridinyl)-1H-pyrazol-4-yl]quinoline; E 616451; HTS 466284. Grades: Highly Purified. CAS No. 396129-53-6. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??N?, Molecular Weight: 272.3. US Biological Life Sciences. |  Worldwide |
| LY-364947 | LY-364947 (HTS466284) is a potent ATP-competitive inhibitor of TGF?R-I with IC50 of 59 nM, and exhibits 7-fold selectivity over TGF?R-II[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: HTS466284. CAS No. 396129-53-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13462. |  |
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