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3PO. Group: Biochemicals. Grades: Purified. CAS No. 13309-08-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
3PO
3PO inhibits PFKFB3 (IC50 = 25 μM) and has the potential to inhibit the proliferation of cancer cells. Synonyms: (E)-3PO; (E)-3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one; 3PO (inhibitor of glucose metabolism); 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-; (2E)-3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one; 2-Propen-1-one, 1-(4-pyridyl)-3-(3-pyridyl)-, (E)-. Grade: ≥95%. CAS No. 18550-98-6. Molecular formula: C13H10N2O. Mole weight: 210.23.
3PO
3PO is an inhibitor of PFKFB3. 3PO attenuates the proliferation of several cancer cell lines with IC 50 s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD + and NADH. 3PO can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 18550-98-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19824.
A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one
3PO is originally reported to inhibit PFKFB3 (IC50 = 25 μM), with the potential to inhibit cancer cell proliferation. The addition of selective inhibitors of autophagy to 3PO and its more potent derivatives may prove useful as rational combinations for the treatment of cancer. Synonyms: 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-; 2-Propen-1-one, 3-(3-pyridyl)-1-(4-pyridyl)-; 3-(pyridin-3-yl)-1-(pyridin-4-yl)prop-2-en-1-one; rac 3PO. Grade: ≥95%. CAS No. 13309-08-5. Molecular formula: C13H10N2O. Mole weight: 210.23.
Benzyltriphenylphosphonium hydroxide
Benzyltriphenylphosphonium hydroxide. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Benzyltriphenylphosphonium hydroxide;Ethyl Triphenylphosphonium Hydroxide;Methyl Triphenylphosphonium Hydroxide;N-Propyl triphenylphosphonium hydroxide;Tetramethylphosphonium hydroxide;Tetrapropylphosphonium hydroxide. Product Category: Heterocyclic Organic Compound. CAS No. 2035-71-4. Molecular formula: (C6H5CH2)(C6H5)3POH. Product ID: ACM2035714. Alfa Chemistry ISO 9001:2015 Certified.
PFK-015, a derivative of 3PO, is a specific PFKFB3 inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. PFK-015 can be used for the research of multiple cancers such as lung cancer, stomach cancer, colon cancer and esophageal squamous cell carcinoma (ESCC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4382-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12204.