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| Product | Description | |
|---|---|---|
| 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one | 4,5-Dichloro-2-m-tolylpyridazin-3(2H)-one. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,5-dichloro-2-(3-methylphenyl)pyridazin-3(2H)-one, 4,5-Dichloro-2-(m-tolyl)pyridazin-3(2H)-one, 41931-13-9, ZINC00272295, pyridazinone, 2-46, AC1LFKOK, AC1Q3HAC, SureCN3031931, MLS001001689, CHEMBL607553, CTK6C1272, MolPort-000-894-037, HMS2821H07, ANW-72439, AR-1F8329, SBB035960, STK399956, AKOS000313169, AG-B-98042, MCULE-5858485606. Product Category: Heterocyclic Organic Compound. CAS No. 41931-13-9. Molecular formula: C11H8Cl2N2O. Mole weight: 255.100020 [g/mol]. Purity: 0.96. IUPACName: 4,5-dichloro-2-(3-methylphenyl)pyridazin-3-one. Canonical SMILES: CC1=CC(=CC=C1)N2C(=O)C(=C(C=N2)Cl)Cl. Density: 1.39g/cm³. Product ID: ACM41931139. Alfa Chemistry ISO 9001:2015 Certified. |  |
| SOD1 Inhibitor, LCS-1 (4,5-dichloro-2-(3-methylphenyl)-3(2H)-pyridazinone, 4,5-dichloro-2-m-tolylpyridazin-3(2H)-one, Superoxide Dismutase 1 Inhibitor, Lung Cancer Screen 1) | A 2-phenylpyridazin-3(2H)-one based non-copper chelater that selectively inhibits the activity of Superoxide dismutase 1 (Cu/Zn-SOD) (IC50=1.07uM). Cells over-expressing SOD1 show reduced sensitivity to LCS-1. Shown to preferably inhibit the growth of a variety of human lung adenocarinoma cell lines with EGFR and KRAS mutations (IC50=200nM). Prevents serum-induced activation of the ERK and PI 3-kinase/AKT signaling thereby affecting cell growth and survival. Apparent half-life of this compound is reported to be 6.6min in human liver microsomes. Group: Biochemicals. Grades: Highly Purified. CAS No. 41931-13-9. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
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