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Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Group: Biochemicals. Alternative Names: FHPI, 4-(4-Fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)-1H-imidazole. Grades: Highly Purified. CAS No. 152121-30-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C20H14FN3O. US Biological Life Sciences.
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Flutrimazole
Flutrimazole, an imidazole antifungal agent with anti-inflammatory activity, has potent and broad-spectrum in vitro activity against dermatophytes, filamentous fungi and yeasts. Uses: Antifungal agents. Synonyms: 1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole; UR 4056; 1-(o-Fluoro-α-(p-fluorophenyl)-α-phenylbenzyl)imidazole; 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-. Grade: ≥95%. CAS No. 119006-77-8. Molecular formula: C22H16F2N2. Mole weight: 346.37.
Potential inhibitor of glucagon receptors, also used in the synthesis of p38 MAP kinase inhibitors. Group: Biochemicals. Alternative Names: 4-[5-(4-Fluorophenyl)-2-[4-(methylthio)phenyl]-1H-imidazol-4-yl]pyridine. Grades: Highly Purified. CAS No. 152121-44-3. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
LY2228820
LY2228820. Group: Biochemicals. Alternative Names: 5-[2-(1,1-Dimethylethyl)-5-(4-fluorophenyl)-1H-imidazol-4-yl]-3-(2,2-dimethylpropyl)-3H-imidazo[4,5-b]pyridin-2-amine dimethanesulfonate. Grades: Highly Purified. CAS No. 862507-23-1. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H37FN6O6S2. US Biological Life Sciences.
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RWJ 67657
RWJ 67657 is an orally active inhibitor of the MAP kinases p38alpha and p38beta (IC50s = 1 and 11 uM, respectively, in vitro) that is inactive against p38gamma and p38delta, as well as several other kinases. It blocks the release of TNF-alpha and IL-1beta from peripheral blood mononuclear cells stimulated with LPS (IC50s = 3 and 11 nM, respectively) and inhibits TNF-alpha production in LPS-treated mice and rats. RWJ 67657 potently blocks the proliferation of CD4+ peripheral blood T cells induced by CD28 stimulation alone (IC50 = 0.5-4nM). It is commonly used to study the roles of p38alpha and p38beta in cellular and whole animal systems. Group: Biochemicals. Alternative Names: 4-[4-(4-Fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-3-butyn-1-ol; 4-(4-Fluorophenyl)-2-(4-hydroxy-1-butynyl)-1-(3-phenylpropyl)-5-(4-Pyridyl)imidazole; JNJ 3026582; RWJ 67657. Grades: Highly Purified. CAS No. 215303-72-3. Pack Sizes: 1mg, 5mg, 10mg, 50mg. US Biological Life Sciences.
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SB 202190
Potent and cell permeable p38 MAP kinase inhibitor. Apoptosis inducer. Inhibits p38alpha and beta, but not gamma and delta isoforms. Does not inhibit ERK2 or other members of the MAP kinase family or their upstream activators. JNK activator. Group: Biochemicals. Alternative Names: 4-[4-(4-Fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol. Grades: Highly Purified. CAS No. 152121-30-7. Pack Sizes: 5mg. Molecular Formula: C20H14FN3O. US Biological Life Sciences.
Worldwide
SB 202190 hydrochloride
SB 202190 hydrochloride. Group: Biochemicals. Alternative Names: 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol monohydrochloride. Grades: Highly Purified. CAS No. 350228-36-3. Pack Sizes: 5mg, 10mg, 25mg. Molecular Formula: C20H15ClFN3O. US Biological Life Sciences.
Worldwide
SB 203580 Hydrochloride Salt
SB 203580 Hydrochloride Salt. Group: Biochemicals. Alternative Names: 4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine; hydrochloride; SB203580 hydrochloride; SCHEMBL4890447; HY-10256A. Grades: Highly Purified. CAS No. 869185-85-3. Pack Sizes: 10mg, 25mg. Molecular Formula: C21 H16 FN 3 , Molecular Weight: 413.9. US Biological Life Sciences.
Worldwide
(S)-p38 MAPK Inhibitor III
(S)-p38 MAPK inhibitor III is a methylsulfanylimidazole that inhibits p38 MAP kinase (IC50 = 0.90 μM in vitro). It is cell-permeable, potently blocking the release of TNF-α and IL-1β from human peripheral blood mononuclear cells (IC50s = 0.37 and 0.044 μM, respectively). Synonyms: (S)-p38 MAP Kinase Inhibitor III; 4-[5-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-4-yl]-N-[(1S)-1-phenylethyl]-2-pyridinamin; (S)-p38 Mitogen-activated Protein Kinase Inhibitor III. Grade: ≥98%. CAS No. 581098-48-8. Molecular formula: C23H21FN4S. Mole weight: 404.5.
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