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| Product | Description | |
|---|---|---|
| 4-Demethylwyosine | 4-Demethylwyosine is a biomedicine used in the treatment of certain cancers and chronic diseases. It functions as a potential anticancer agent by targeting specific cellular pathways and inhibiting tumor growth. This compound exhibits promising results in combating various types of cancer, including breast, lung, and colon cancer. Synonyms: N4-Desmethylwyosine; imG-14; 9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-6-methyl-3-β-D-ribofuranosyl-; 6-methyl-3-(beta-D-ribofuranosyl)-3,5-dihydro-9H-imidazo[1,2-a]purin-9-one; 1,N2-Isopropenoguanosine; 1,N-(2-Methyl-1,2-ethenediyl)guanosine; 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-6-methyl-5H-imidazo[1,2-a]purin-9-one. Grades: ≥95%. CAS No. 59327-60-5. Molecular formula: C13H15N5O5. Mole weight: 321.29. |  |
| tRNA 4-demethylwyosine synthase (AdoMet-dependent) | This enzyme, which is a member of the superfamily of S-adenosyl-L-methionine-dependent radical (radical AdoMet) enzymes, binds two [4Fe-4S] clusters. Carbons C2 and C3 from pyruvate are incorporated into 4-demethylwyosine. The enzyme is found in eukaryotes where it is part of the pathway for wybutosine synthesis, and in archaea, where it is involved in the biosynthesis of archaeal wye bases, such as wyosine, isowyosine, and methylwyosine. Group: Enzymes. Synonyms: TYW1. Enzyme Commission Number: EC 4.1.3.44. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4921; tRNA 4-demethylwyosine synthase (AdoMet-dependent); EC 4.1.3.44; TYW1. Cat No: EXWM-4921. |  |
| tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase | The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases. This modification is essential for translational reading-frame maintenance. The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNAPhe. Group: Enzymes. Synonyms: TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name). Enzyme Commission Number: EC 2.5.1.114. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2730; tRNAPhe (4-demethylwyosine37-C7) aminocarboxypropyltransferase; EC 2.5.1.114; TYW2; tRNA-yW synthesizing enzyme-2; TRM12 (gene name); taw2 (gene name). Cat No: EXWM-2730. | |
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