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2-[(4-methoxyphenyl)methoxy]ethyl 4-methylbenzene-1-sulfonate. Uses: Designed for use in research and industrial production. Product Category: PROTAC Library. CAS No. 354507-05-4. Molecular formula: C17H20O5S. Mole weight: 336.4027. Product ID: PR354507054. Alfa Chemistry ISO 9001:2015 Certified.
2-O-DMT-sulfonyldiethanol phosphoramidite
2-O-DMT-sulfonyldiethanol phosphoramidite substantiates its inevitable prowess in the synthesis and alteration of nucleic acids across diverse applications. Unparalleled in its chemical composition, this exceptional concoction facilitates meticulous and efficient manipulation of nucleic acids, thus fostering elevated biomedical exploration with incomparable precision. Synonyms: 2- ( (2- (bis (4-methoxyphenyl) (phenyl)methoxy)ethyl)sulfonyl)ethyl (2-cyanoethyl) diisopropylphosphoramidite; Phosphoramidous acid, N,N-bis(1-methylethyl)-, 2-[[2-[bis (4-methoxyphenyl) phenylmethoxy]ethyl]sulfonyl]ethyl 2-cyanoethyl ester; 2-[2- (4, 4'-dimethoxytrityloxy) ethylsulfonyl]ethyl- (2-cyanoethyl) - (N, N-diisopropyl) -phosphoramidite; 2-O-DMT-S phosphoramidite. Grades: >95% by HPLC. CAS No. 108783-02-4. Molecular formula: C34H45N2O7PS. Mole weight: 656.77.
Methyl 1-[(4-methoxyphenyl)sulfonyl]-1H-indole-3-carboxylate. Uses: Designed for use in research and industrial production. Additional or Alternative Names: METHYL 1-[(4-METHOXYPHENYL)SULFONYL]-1H-INDOLE-3-CARBOXYLATE;1H-INDOLE-3-CARBOXYLIC ACID, 1-[(4-METHOXYPHENYL)SULFONYL]-,METHYL ESTER. Product Category: Heterocyclic Organic Compound. CAS No. 866145-32-6. Molecular formula: C17H15NO5S. Mole weight: 345.37. Product ID: ACM866145326. Alfa Chemistry ISO 9001:2015 Certified.
ML277
ML277, a sulfonylpiperidine compound, has been found to be a KCNQ1 K+ channel activator and could be used in the study of the activity of K+ channel in human cardiomyocytes. IC50: 270 nM (EC50). Uses: Ml277 has been found to be a kcnq1 k+ channel activator and could be used in the study of the activity of k+ channel in human cardiomyocytes. Synonyms: ML277; ML 277; ML-277; CHEMBL2070953; (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide; ML 277; 1401242-74-7; MLS003875054. Grades: 98%. CAS No. 1401242-74-7. Molecular formula: C23H25N3O4S2. Mole weight: 471.59.
MMP-3 Inhibitor VIII
MMP-3 inhibitor VIII is a cell-permeable inhibitor of matrix metalloproteinase-3 (MMP-3) with Ki value of 23 nM. It also inhibits mouse macrophage metalloelastase MME/MMP-12. Synonyms: Matrix Metalloproteinase-3 Inhibitor VIII; Stromelysin-1 Inhibitor VIII; N-Hydroxy-2(R)-{[(4-methoxyphenyl)sulfonyl]-[benzylamino]}-4-methylpentanamide. Grades: ≥95%. CAS No. 208663-26-7. Molecular formula: C20H26N2O5S. Mole weight: 406.5.
NNGH
NNGH is a cell-permeable inhibitor of matrix metalloproteinases (MMPs). It has been used to study the role of MMP-3 (stromelysin 1) in biological systems. Synonyms: N-Isobutyl-N-(4-methoxyphenylsulfonyl)glycyl hydroxamic acid; ??Matrix Metalloproteinase-3 Inhibitor II; MMP-3 Inhibitor II; N-hydroxy-2-[(4-methoxyphenyl)sulfonyl-(2-methylpropyl)amino]acetamide. Grades: ≥99%. CAS No. 161314-17-6. Molecular formula: C13H20N2O5S. Mole weight: 316.4.
A cell-permeable phenyl sulfonyl oxyimi nocyclohexadienone compound that acts as a potent, selective, and reversible inhibitor of p300 histone acetyl transferase (IC50 = 1.98uM). Shown to occupy Ac-CoA binding pocket of p300, and less potent to CBP, PCAF, GCN5 and GNAT. Suppresses Histone H3 and H4 acetylation in triple negative breast cancer cell line MDAMB-468 as well as in HCT116 cell line and blocks p300-mediated STAT3 phosphorylation in pancreatic cancer cell line MIA Paca-2. Does neither inhibit the activities of histone deacetylases 1, 6, and 11 nor 8-diverse histone methyltransferases tested (DOT1, EZH1, G9a, PRMT1, SETD2, SET7-9, SMYD2, and SUV39H2). Reported to suppress tumor growth in mice bearing tumor xenografts of MDAMB-468 cell line (at 500ug/100ul, i.p. twice a week). Group: Biochemicals. Grades: Highly Purified. CAS No. 321695-57-2. Pack Sizes: 10mg. Molecular Formula: C??H??NO?S. US Biological Life Sciences.
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TASIN-1
TASIN-1 is an inhibitor of adenomatous polyposis coli (APC) that kills colorectal cancer cells that express APC by reducing cellular cholesterol levels. It also inhibits AKT activity through a cholesterol-dependent manner. Synonyms: 1'-[(4-Methoxyphenyl)sulfonyl]-4-methyl-1,4'-bipiperidine. Grades: ≥98%. CAS No. 792927-06-1. Molecular formula: C18H28N2O3S. Mole weight: 352.5.
YU238259
YU238259 is a novel inhibitor of homology-dependent DNA repair (HDR) while not inhibiting non-homologous end-joining in cell-based GFP reporter assays. Treatment with YU238259 is not only synergistic with ionizing radiation (IR), etoposide, and PARP inhibition, but this synergism is heightened by BRCA2-deficiency. Synonyms: YU238259; YU 238259; YU-238259; SCHEMBL17912765; ZINC669685255; N-[2- (5-chloropyridin-2-yl) ethyl]-4-[[ (4-methoxyphenyl) sulfonylamino]methyl]benzamide. Grades: 99.28 %. CAS No. 1943733-16-1. Molecular formula: C22H22ClN3O4S. Mole weight: 459.95.
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