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| Product | Description | |
|---|---|---|
| 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine | 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ALK5 INHIBITOR I;2-(3-(6-METHYLPYRIDIN-2-YL)-1H-PYRAZOL-4-YL)-1,5-NAPHTHYRIDINE;TGF-BETA RI KINASE INHIBITOR II;TRANSFORMING GROWTH FACTOR-BETA TYPE I RECEPTOR KINASE INHIBITOR I;2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;SJN 2511;2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine;RepSox. CAS No. 446859-33-2. Molecular formula: C17H13N5. Mole weight: 287.31862. Purity: 98%+. IUPACName: 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine. Canonical SMILES: CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4. Density: 1.297g/cm³. Product ID: ACM446859332. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Alk 5 Inhibitor II | Alk 5 Inhibitor II. Group: Biochemicals. Alternative Names: 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine; E 616452; RepSox; SJN 2511. Grades: Highly Purified. CAS No. 446859-33-2. Pack Sizes: 10mg. Molecular Formula: C17H13N5, Molecular Weight: 287.32. US Biological Life Sciences. |  Worldwide |
| ALK5 Inhibitor II hydrochloride | ALK5 inhibitor II was identified as a cell permeable, selective inhibitor of the TGF-β type 1 activin like kinase receptor ALK5 (ALK5 autophosphorylation, IC50s = 4 nM, TGF-β cellular assay, IC50s = 18 nM, ALK5 binding in HepG2 cells, IC50s = 23 nM). This compound has been used to induce stem cell pluripotency by replacing the reprogramming transcription factor Sox2 via inhibition of the TGF-β signaling pathway and induction of Nanog transcription. This product is a hydrochloride form. Synonyms: E 616452; RepSox; SJN 2511. Grades: ≥98%. CAS No. 446859-33-2. Molecular formula: C17H13N5·HCl. Mole weight: 323.8. |  |
| RepSox | RepSox (E-616452) is a potent and selective transforming growth factor-beta receptor I/activin like kinase 5 (TGF-β-RI/ALK5) inhibitor. RepSox inhibits ALK5 autophosphorylation with an IC 50 value of 4 nM. RepSox can be used for the research of obesity and associated metabolic diseases such as type 2 diabetes [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-616452; SJN 2511. CAS No. 446859-33-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13012. |  |
| RepSox | RepSox. Group: Biochemicals. Grades: Purified. CAS No. 446859-33-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| RepSox (2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, E-616452) | Cell-permeable. A TGF-b type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC??=4nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription. Group: Biochemicals. Grades: Highly Purified. CAS No. 446859-33-2. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
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