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| Product | Description | |
|---|---|---|
| Jervine | Jervine (11-Ketocyclopamine) is a potent Hedgehog (Hh) inhibitor with an IC 50 of 500-700 nM [1]. Jervine is a natural teratogenic sterodial alkaloid from rhizomes of Veratrum nigrum. Jervine has anti-inflammatory and antioxidant properties [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 11-Ketocyclopamine. CAS No. 469-59-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-N0836. |  |
| Jervine | Jervine. Group: Biochemicals. Grades: Purified. CAS No. 469-59-0. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Jervine | Jervine is a natural drug that has been shown to have synergistic effects with other drugs, such as angiogenic processes and matrix effects. Jervine is an ester hydrochloride derived from the bark of the tree Jervisia japonica. It has been shown to have significant cytotoxicity against human leukemia cells HL-60 in vitro. The mechanism of action of jervine is not yet fully understood, but it may be due to the presence of nitrogen atoms or sesquiterpene lactones. Group: Other alkaloids. Alternative Names: (3β,23β)-17,23-Epoxy-3-hydroxyveratraman-11-one. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.6 g/mol. Canonical SMILES: C[C@H]1C[C@@H]2[C@H] ([C@H] ([C@]3 (O2)CC[C@H]4[C@@H]5CC=C6C[C@H] (CC[C@@]6 ([C@H]5C (=O)C4=C3C)C)O)C)NC1. Catalog: ACM469590. |  |
| Jervine | Jervine is a naturally occuring steroidal alkaloid that causes cyclopia by blocking sonic hedgehog(Shh) signaling. It is an inhibitor of Smo and derived from the Veratrum plant species. Jervine can be used to induce abnormal morphogenesis in a number of experimental models. Uses: Antibacterial. Synonyms: Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-; (2'R, 3S, 3'R, 3'aS, 6'S, 6aS, 6bS, 7'aR, 11aS, 11bR)-2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-Hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethylspiro[9H-benzo[a]fluorene-9, 2'(3'H)-furo[3, 2-b]pyridin]-11(1H)-one; Veratraman-11-one, 17,23-epoxy-3-hydroxy-, (3β,23β)-; Jervin; NSC 23898; NSC 7520; Spiro[9H-benzo[a]fluorene-9,2'(3'H)-furo[3,2-b]pyridin]-11(1H)-one, 2, 3, 3'a, 4, 4', 5', 6, 6', 6a, 6b, 7, 7', 7'a, 8, 11a, 11b-hexadecahydro-3-hydroxy-3', 6', 10, 11b-tetramethyl-, [3S-(3α, 6aα, 6bβ, 9α(3'S*, 3'aR*, 6'R*, 7'aS*), 11aβ, 11bα)]-. Grades: >98%. CAS No. 469-59-0. Molecular formula: C27H39NO3. Mole weight: 425.60. |  |
| Jervine | Jervine - Product ID: NST-10-170. Category: Alkaloids. Purity: 98%. Test method: HPLC. CAS No. 469-59-0. Pack Sizes: 0,05g, 0,1g, 0,25g, 0,5g. Appearance: White to off-white powder. Molecular formula: C27H39NO3. Mole weight: 425.61. Storage: +2 +8 °C. |  |
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