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| Product | Description | |
|---|---|---|
| 5'-Iodoresiniferatoxin | 5'-Iodoresiniferatoxin is a very potent and strong competitive antagonist of the transient receptor potential vanilloid 1 (TRPV1) receptor. It is derived from resiniferatoxin (RTX), which is produced by the Moroccan succulent Euphorbia resinifera. It is iodinated at the 5-position and can be prepared from RTX by electrophilic aromatic substitution. It binds to TRPV1 (VR1) receptors expressed in HEK293 cells with Kd value of 4.3 nM and Ki value of 5.8 nM. It binds to the VR1 receptor with high affinity but does not induce RTX- or capsaicin-like effects in Xenopus laevis oocytes expressing VR1. It is 40-fold more potent than capsazepine. Synonyms: 5-I-RTX; 5'-IRTX; 6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(phenylmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzeneacetate). Grades: ≥98% by HPLC. CAS No. 535974-91-5. Molecular formula: C37H39IO9. Mole weight: 754.60. |  |
| 5'-Iodoresiniferatoxin | Potent, silent TRPV1 antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 535974-91-5. Pack Sizes: 1mg. Molecular Formula: C37H39IO9. US Biological Life Sciences. |  Worldwide |
| 6'-Iodoresiniferatoxin | 6'-Iodoresiniferatoxin. Group: Biochemicals. Grades: Purified. CAS No. 335151-55-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 6'-Iodoresiniferatoxin | 6'-Iodoresiniferatoxin is a partial and high affinity TRPV1 (VR1) vanilloid receptor agonist with EC50 value of 130 nM and Ki value of 0.71 nM. It shows partial agonism at human VR1 and full agonism at rat VR1. Synonyms: 6'-IRTX; [(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]-4-hydroxy-2-iodo-5-methoxy-benzeneacetic acid methyl ester. Grades: ≥98% by HPLC. CAS No. 335151-55-8. Molecular formula: C37H39IO9. Mole weight: 754.60. | |
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