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| Product | Description | |
|---|---|---|
| 5-(4-Phenoxybutoxy)psoralen | 5-(4-Phenoxybutoxy)psoralen is selective inhibitor of Kv1.3, voltage-gated K+ channel. It potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. It has 23-fold selectivity for Kv1.3 over Kv1.5. It is used in treatment of multiple sclerosis. It was developed by Airmid company and is in Cilinic phase 1. Uses: 5-(4-phenoxybutoxy)psoralen is used in treatment of multiple sclerosis. Synonyms: SPS-4251; SPS 4251; SPS4251; AS-77; PAP-1; AS 77; PAP 1; AS77; PAP1; 7H-Furo[3,2-g][1]benzopyran-7-one, 4-(4-phenoxybutoxy)-; 4-(4-Phenoxybutoxy)-7H-furo[3,2-g][1]benzopyran-7-one; 2-g][1]benzopyran-7-one; 4-(4-phenoxybutoxy)-7H-furo[3,2-g]chromen-7-one. Grade: 95%. CAS No. 870653-45-5. Molecular formula: C21H18O5. Mole weight: 350.36. |  |
| 5-(4-Phenoxybutoxy)psoralen | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| PAP-1 | PAP-1 (5-(4-Phenoxybutoxy)psoralen) is a potent, selective, and orally active Kv1.3 blocker (EC50=2 nM). PAP-1 blocks Kv1.3 in a use-dependent manner and acts by preferentially binding to the C-type inactivated state of the channel. PAP-1 exhibits 23-fold selectivity over Kv1.5 (EC50=45 nM), and further displays 33- to 125-fold selectivity over all other Kv1-family channels. PAP-1 does not exhibit cytotoxic or phototoxic effects[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 5-(4-Phenoxybutoxy)psoralen. CAS No. 870653-45-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10015. |  |
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