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| Product | Description | |
|---|---|---|
| AST487 | AST487 / NVP-AST487 is a RET kinase inhibitor/FLT3 inhibitor with an IC(50) of 0.88 mumol/L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibiting the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. Group: Fluorinated apis. Alternative Names: NVP-AST487. CAS No. 630124-46-8. Molecular formula: C26H30F3N7O2. Mole weight: 529.56. Appearance: White to off-white solid powder. Purity: >98%. IUPACName: 1-[4-[ (4-ethylpiperazin-1-yl)methyl]-3- (trifluoromethyl)phenyl]-3-[4-[6- (methylamino)pyrimidin-4-yl]oxyphenyl]urea. Catalog: OFC630124468. |  |
| AST 487 | AST 487 Inhibitor. Uses: Scientific use. Product Category: T4053. CAS No. 630124-46-8. |  |
| AST 487 | AST487 is a Ret kinase inhibitor/FLT3 inhibitor, which displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML. It induced a dose-dependent growth inhibition of xenografts of NIH3T3 cells expressing oncogenic RET, and of the MTC cell line TT in nude mice.It also inhibited calcitonin gene expression in vitro in TT cells, in part, through decreased gene transcription. Synonyms: NVP-AST 487; NVPAST487; AST 487; AST487; AST-487. Grades: >98%. CAS No. 630124-46-8. Molecular formula: C26H30F3N7O2. Mole weight: 529.56. |  |
| AST-487 | Potent RET kinase inhibitor. AST 487 displays high selectivity and potency toward FLT3 as a molecular target, and which could potentially be used to override drug resistance in AML. Group: Biochemicals. Grades: Highly Purified. CAS No. 630124-46-8. Pack Sizes: 1mg, 5mg. US Biological Life Sciences. |  Worldwide |
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