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7,8-Dihydroneopterin, an inflammation marker, induces cellular apoptosis in astrocytes and neurons via enhancement of nitric oxide synthase ( iNOS ) expression. 7,8-Dihydroneopterin can be used in the research of neurodegenerative diseases [1]. Uses: Scientific research. Group: Natural products. CAS No. 1218-98-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-136341.
Contains one zinc atom and one iron atom per subunit of the dodecameric enzyme. It hydrolyses 7,8-dihydroneopterin 2',3'-cyclic phosphate, a step in tetrahydromethanopterin biosynthesis. In vitro the enzyme forms 7,8-dihydroneopterin 2'-phosphate and 7,8-dihydroneopterin 3'-phosphate at a ratio of 4:1. Group: Enzymes. Synonyms: MptB. Enzyme Commission Number: EC 3.1.4.56. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3739; 7,8-dihydroneopterin 2',3'-cyclic phosphate phosphodiesterase; EC 3.1.4.56; MptB. Cat No: EXWM-3739.
7,8-dihydroneopterin epimerase
The enzyme, which has been characterized in bacteria and plants, also has the activity of EC 4.1.2.25, dihydroneopterin aldolase. The enzyme from the bacterium Mycobacterium tuberculosis has an additional oxygenase function (EC 1.13.11.81, 7,8-dihydroneopterin oxygenase). Group: Enzymes. Enzyme Commission Number: EC 5.1.99.8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5440; 7,8-dihydroneopterin epimerase; EC 5.1.99.8. Cat No: EXWM-5440.
7,8-dihydroneopterin oxygenase
The enzyme from the bacterium Mycobacterium tuberculosis is multifunctional and also catalyses the epimerisation of the 2'-hydroxy group of 7,8-dihydroneopterin (EC 5.1.99.8, 7,8-dihydroneopterin epimerase) and the reaction of EC 4.1.2.25 (dihydroneopterin aldolase). Group: Enzymes. Enzyme Commission Number: EC 1.13.11.81. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0602; 7,8-dihydroneopterin oxygenase; EC 1.13.11.81. Cat No: EXWM-0602.
7,8-Dihydro-D-Neopterin
7,8-Dihydro-D-Neopterin is an intermediate in the biosynthesis of Biopterin (sc-204781). 7,8-Dihydro-D-Neopterin, also known as Dihydroneopterin, is closely related to tetrahydrobiopterin, an important cofactor in humans. Applications: An intermediate in the biosynthesis of tetrahydrobiopterin. Group: Coenzymes. Synonyms: 7,8-Dihydroneopterin; Dihydroneopterin. CAS No. 1218-98-0. Mole weight: 255.2. Appearance: Powder. Form: Solid. 7,8-Dihydroneopterin; Dihydroneopterin; 7,8-Dihydro-D-Neopterin; 1218-98-0. Cat No: COEC-063.
Dihydroneopterin
Dihydroneopterin. Group: Biochemicals. Alternative Names: 2-Amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(3H)-pteridinone; D-Erythro-1-(2-amino-7,8-dihydro-4-hydroxy-6-pteridinyl)-1,2,3-propanetrio; [S-(R*,S*)]-2-Amino-7,8-dihydro-6-(1,2,3-trihydroxypropyl)-4(1H)-pteridinone; 2-Amino-7,8-dihydro-6-[(1S,2R)-1,2,3-trihydroxypropyl]-4(1H)-pteridinone; 2-Amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine; 2-Amino-4-hydroxy-6-(D-erythro-1',2',3'-trihydroxypropyl)-7,8-dihydropteridine; 7,8-Dihydro-D-erythro-neopterin; 7,8-Dihydro-D-neopterin; 7,8-Dihydroneopterin; D-erythro-7,8-Dihydroneopterin. Grades: Highly Purified. CAS No. 1218-98-0. Pack Sizes: 25mg. Molecular Formula: C9H13N5O4, Molecular Weight: 255.23. US Biological Life Sciences.
Worldwide
dihydroneopterin aldolase
The enzyme participates in folate (in bacteria, plants and fungi) and methanopterin (in archaea) biosynthesis. The enzymes from the bacterium Escherichia coli and the plant Arabidopsis thaliana also catalyse the epimerisation of the 2' hydroxy-group (EC 5.1.99.8, 7,8-dihydroneopterin epimerase). The enzyme from the bacterium Mycobacterium tuberculosis is trifunctional and also catalyses EC 5.1.99.8 and EC 1.13.11.81, 7,8-dihydroneopterin oxygenase. The enzyme from the yeast Saccharomyces cerevisiae also catalyses the two subsequent steps in the folate biosynthesis pathway - EC 2.7.6.3, 2-amino-4-hydroxy-6-(hydroxymethyl)dihydropteridine diphosphokinase, and EC 2.5.1.15, dihydropteroate synthase. Group: Enzymes. Synonyms: 7,8-dihydroneopterin aldolase; 2-amino-. Enzyme Commission Number: EC 4.1.2.25. CAS No. 37290-59-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4864; dihydroneopterin aldolase; EC 4.1.2.25; 37290-59-8; 7,8-dihydroneopterin aldolase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase; 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming); DHNA; mptD (gene name); folB (gene name). Cat No: EXWM-4864.
dihydroneopterin triphosphate 2'-epimerase
The enzyme, found in gammaproteobacteria, has almost no activity with 7,8-dihydroneopterin. Group: Enzymes. Synonyms: D-erythro-7,8-dihydroneopterin triphosphate epimerase; folX (gene name). Enzyme Commission Number: EC 5.1.99.7. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5439; dihydroneopterin triphosphate 2'-epimerase; EC 5.1.99.7; D-erythro-7,8-dihydroneopterin triphosphate epimerase; folX (gene name). Cat No: EXWM-5439.
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