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| Product | Description | |
|---|---|---|
| 7-Ethyl Camptothecin | An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione; 7-Ethyl-20(S)-camptothecin; SN 22. Grades: Highly Purified. CAS No. 78287-27-1. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| 7-Ethyl Camptothecin | The main reasons for the superior antitumor activity of 7-Ethylcamptothecin compared with CPT are as follows: (a) 7-Ethylcamptothecin had a stronger growth-inhibiting activity against tumor cells, and (b) 7-Ethylcamptothecin remained in the intestinal tract for a longer time and in higher amounts when administered in vivo. 7-Ethyl Camptothecin is a natural compound found in the barks of Camptotheca acuminata Decne, it can be used as a cosmetics material. Synonyms: (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione; 7-ethylcamptothecin; (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; Irinotecan EP Impurity F. Grades: >98%. CAS No. 78287-27-1. Molecular formula: C22H20N2O4. Mole weight: 376.42. |  |
| 7-Ethyl-10-hydroxycamptothecin | 7-Ethyl-10-hydroxycamptothecin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 7-10-Hydroxycamptothecin. Appearance: Powder. CAS No. 86639-52-3. Molecular formula: C22H20N2O5. Mole weight: 392.4. Purity: 0.98. IUPACName: (19S)-10,19-diethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione. Canonical SMILES: CCC1=C2CN3C(=CC4=C(C3=O)COC(=O)[C@@]4(CC)O)C2=NC5=C1C=C(C=C5)O. Density: 1.51±0.1 g/ml. Product ID: ACM86639523. Alfa Chemistry ISO 9001:2015 Certified. Categories: 7-ethyl-10-hydroxy-camptothecin. |  |
| 7-Ethyl-10-Hydroxy-Camptothecin | 7-Ethyl-10-Hydroxy-Camptothecin. Group: Biochemicals. Alternative Names: 10-Hydroxy-7-ethylcamptothecin; 7-Ethyl-10-hydroxy-20(S)-camptothecin. Grades: Plant Grade. CAS No. 86639-52-3. Pack Sizes: 20mg. Molecular Formula: C22H20N2O5, Molecular Weight: 392.405. US Biological Life Sciences. | Worldwide |
| 7-Ethylcamptothecin | 7-Ethylcamptothecin is one of camptothecin analogues. camptothecin (CPT), a cytotoxic alkaloid isolated from Camptotheca acuminata , is shown to have strong antitumor activity against L1210 leukemia and Walker 256 carcinosarcoma models [1]. Uses: Scientific research. Group: Natural products. CAS No. 78287-27-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 250 mg. Product ID: HY-N2108. |  |
| 7-Ethyl-d3-camptothecin | An anticancer drug, showed strong activity against various murine tumors. A Labeled camptothecin(CPT) derivative as antineoplastic agent against drug-resistant tumors. Group: Biochemicals. Alternative Names: (4S)-4, 11-Diethyl-4-hydroxy-1H-pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-3, 14(4H, 12H)-dione-d3; 7-Ethyl-d3-20(S)-camptothecin; SN 22-d3. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Etirinotecan pegol | Etirinotecan pegol, also know as pegylated irinotecan, NKTR102, is a formulation of polyethylene glycol (PEG)-encapsulated irinotecan with antineoplastic activity. The prodrug irinotecan, a semisynthetic derivative of camptothecin, is converted to the biologically active metabolite 7-ethyl-10-hydroxy-camptothecin by a carboxylesterase-converting enzyme. One thousand-fold more potent than its parent compound irinotecan, 7-ethyl-10-hydroxy-camptothecin inhibits topoisomerase I activity by stabilizing the cleavable complex of topoisomerase I and DNA, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. Pegylation provides improved drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile. Synonyms: NKTR102; NKTR 102; NKTR-102; pegylated irinotecan NKTR 102; Etirinotecan pegol. CAS No. 1193151-09-5. Molecular formula: C161H196Cl4N20O40. Mole weight: 3193.24. | |
| Irinotecan, Hydrochloride Salt, Trihydrate ([1,4-Bipiperidine]-1-carboxylic Acid (S)-4, 11-diethyl-3, 4, 12, 14-tetrahydro-4-hydroxy-3, 14-dioxo-1H-pyrano[3, 4, 6, 7]indolizino[1, 2-b]quinolin-9-yl Ester, HCl Trihydrate) | Irinotecan (CPT-11) is a topoisomerase I inhibitor. It is a semisynthetic analog of the natural alkaloid camptothecin and has an active metabolite SN-38 (7-Ethyl-10-hydroxycamptothecin). During the S phase of the cell cycle, camptothecins selectively bind to and stabilize topoisomerase I-DNA complexes, inhibiting religation, causing the accumulation of topoisomerase I-mediated single-strand DNA breaks in the DNA, and producing irreversible double-strand DNA breaks that lead to cell death. Group: Biochemicals. Grades: Highly Purified. CAS No. 136572-09-3. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| Irinotecan Hydrochloride Trihydrate | The hydrochloride salt of Irinotecan. Irinotecan is a prodrug that can be activated to 7-ethyl-10-hydroxy-camptothecin (SN-38) by the carboxylesterase-converting enzyme. SN-38 inhibits topoisomerase I to suppress DNA replication and promote cell death. Synonyms: CPT-11 HCl Trihydrate; CPT 11 HCl Trihydrate; CPT11 HCl Trihydrate; Irinotecan Hcl Trihydrate; UNII-042LAQ1IIS. Grades: >98%. CAS No. 136572-09-3. Molecular formula: C33H38N4O6.HCl.3H2O. Mole weight: 677.18. | |
| SN-38 Glucuronide | A metabolite of Irinotecan. Synonyms: 7-Ethyl-10-hydroxy-camptothecin-10-O-b-Dglucuronide; (4S)-4,11-Diethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-9-yl b-D-glucopyranosiduronic acid. Grades: > 95%. CAS No. 121080-63-5. Molecular formula: C28H28N2O11. Mole weight: 568.53. | |
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