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| Product | Description | |
|---|---|---|
| Olaparib | 500mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C24H23FN4O3. CAS No. 763113-22-0. Prepack ID 90027882-500mg. Molecular Weight 434.46. See USA prepack pricing. |  |
| Olaparib | Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC 50 s of 5 and 1 nM for PARP1 and PARP2 , respectively. Olaparib is an autophagy and mitophagy activator [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD2281; KU0059436. CAS No. 763113-22-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg; 1 g; 2 g. Product ID: HY-10162. |  |
| Olaparib | Olaparib is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Olaparib has been shown to induce significant killing of ATM-deficient lymphoid tumor cells in vitro and in vivo. Recent studies show that Olaparib increases radiosensitivity of a lung tumor xenograft, making it a potential candidate for use in combination with radiotherapy.PARP1 acts as a critical molecule in the repair of DNA single-strand breaks (SSBs) and plays an important role in maintaining DNA integrity. de Murcia, J., et al. "Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells." Proc. Natl. Acad. Sci. USA 94: 7303-7307 (1997).PARP inhibitors inhibit PARP1 during S-phase and...num drugs." Proc. Natl. Acad. Sci. USA 105: 17079-17084 (2008).Long-term treatment with olaparib caused the development of drug resistance, which was induced by up-regulation of Abcb1a/b genes encoding P-glycoprotein efflux pumps. The resistance to... Group: Biochemicals. Alternative Names: 4-[[3-[[4-(Cyclopropylcarbonyl)-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinone; AZD-2281; KU 0059436; KU-59436; 1- (Cyclopropylcarbonyl) -4- [5- [ (3, 4-dihydro-4-oxo-1-phthalazinyl) methyl] -2-fluorobenzoyl] piperazine. Grades: Highly Purified. CAS No. 763113-22-0. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??FN?O?, Molecular Weight: 434.46. US Biological Life Sciences. |  Worldwide |
| Olaparib | Olaparib is a selective and potent inhibitor of poly (ADP-ribose) polymerase (PARP) enzymes, PARP1 and PARP2. PARP inhibitors represent a novel class of anti-cancer therapy and they work by taking advantage of a defect in DNA repair in cancer cells with BRCA mutations and inducing cell death. Olaparib is used to treat a number of BRCA-associated tumours, including ovarian cancer, breast cancer, pancreatic cancer, and prostate cancer. Alternative Names: Lynparza AZD2281 AZD-2281. CAS No. 763113-22-0. Product ID: API763113220. Molecular formula: C24H23FN4O3. Mole weight: 434.46. EINECS: 642-941-5. SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F. Appearance: White Solid Powder. Standard: USP/Facility GMP. Category: Anti-Tumor APIs. |  |
| Olaparib (Standard) | Olaparib (Standard) is the analytical standard of Olaparib. This product is intended for research and analytical applications. Olaparib (AZD2281; KU0059436) is a potent and orally active PARP inhibitor with IC50s of 5 and 1 nM for PARP1 and PARP2, respectively. Olaparib is an autophagy and mitophagy activator[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AZD2281 (Standard); KU0059436 (Standard). CAS No. 763113-22-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10162R. | |
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