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| Product | Description | |
|---|---|---|
| Pimobendan hydrochloride | Pimobendan hydrochloride is a selective inhibitor of PDE3. It exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM). It shows a beneficial effect on survival in the murine model of EMC virus-induced myocarditis. It also significantly reduces myocardial cellular infiltration, the level of intracardiac tumor necrosis factor (TNF)-α and interleukin (IL)-1β compared with the control group, which shows no effect on myocardial necrosis, heart weight and body weight. It suppresses expression of the intracardiac iNOS gene , causing reduction of intracardiac NO production. Synonyms: Vetmedin hydrochloride; Acardi hydrochloride. Grades: >98%. CAS No. 77469-98-8. Molecular formula: C19H19ClN4O2. Mole weight: 370.83. |  |
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