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| Product | Description | |
|---|---|---|
| Okadaic acid | Okadaic acid, a marine toxin, is an inhibitor of protein phosphatases (PP). Okadaic acid has a significantly higher affinity for PP2A ( IC 50 =0.1-0.3 nM), and inhibits PP1 ( IC 50 =15-50 nM), PP3 ( IC 50 =3.7-4 nM), PP4 ( IC 50 =0.1 nM), PP5 ( IC 50 =3.5 nM), but does not inhibit PP2C. Okadaic acid increases of phosphorylation of a number of proteins by inhibiting PP, and acts a tumor promoter. Okadaic acid induces tau phosphorylation [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 78111-17-8. Pack Sizes: 25 μg (124.2 μM * 250 μL in Ethanol). Product ID: HY-N6785. |  |
| Okadaic Acid | Okadaic Acid, a marine toxin, polyether derivative produced by dinoflagellates, is a potent, cell-permeable, specific inhibitor of PP-1 and PP-2 serine/threonine-speci?c protein phosphatases in a variety of cell types. Group: Biochemicals. Alternative Names: 9, 10-Deepithio-9, 10-dide hydroacanthifolicin, halochondrine A. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 100ug. US Biological Life Sciences. |  Worldwide |
| Okadaic Acid | Okadaic acid is a marine sponge toxin which potently inhibits certain serine/threonine protein phosphatases. This cell permeable inhibitor targets the multiple isoforms of PP1, both isoforms of PP2A and PP3. It is a very weak inhibitor of PP2B and does not inhibit PP2C or other phosphatases. Synonyms: AA8227800; 9,10-Deepithio-9,10-didehydroacanthifolicin. Grades: 95% by HPLC. CAS No. 78111-17-8. Molecular formula: C44H68O13. Mole weight: 805.00. |  |
| Okadaic Acid | Okadaic acid is a protein phosphatase (PP) inhibitor derived from the marine. Group: Heterocyclic organic compound. Alternative Names: 35-Demethyldinophysistoxin 1. CAS No. 78111-17-8. Molecular formula: C44H68O13. Mole weight: 805. Purity: 95%+. IUPACName: (2R)-3-[(2S,6R,8S,11R)-2-[(E,2R)-4-[(2S,2'R,4R,4aS,6R,8aR)-4-Hydroxy-2-[(1S,3S)-1-hydroxy-3-[(2S,3R,6S)-3-methyl-1,7-dioxaspiro[5.5]undecan-2-yl]butyl]-3-methylidenespiro[4a,7,8,8a-tetrahydro-4H-pyrano[3,2-b]pyran-6,5'-oxolane]-2'-yl]but-3-en-2-yl]-11-hydroxy-4-methyl-1,7-dioxaspiro[5.5]undec-4-en-8-yl]-2-hydroxy-2-methylpropanoic acid. Canonical SMILES: CC1CCC2 (CCCCO2)OC1C (C)CC (C3C (=C)C (C4C (O3)CCC5 (O4)CCC (O5)C=CC (C)C6CC (=CC7 (O6)C (CCC (O7)CC (C) (C (=O)O)O)O)C)O)O. Density: 1.0795 g/cm³. Catalog: ACM78111178. |  |
| Okadaic acid (High Purity) | Non-phorbol type tumor promoter. Reversible, potent and selective serine threonine protein phosphatase inhibitor. PP2A (IC50=0. 2-1nM), PP1 (IC50=3-15nM), PP2B (IC50=>1µM). Does not inhibit PP2C. Stimulates intracellular protein phosphorylation. Useful tool for studying cellular processes that are regulated by phosphorylation. Does not affect activity of acid phosphatase, alkaline phosphatase and tyrosine phosphatase. Mimics the effects of insulin. Activates atypical protein kinase C (zeta/lambda) in 3T3/L1 adipocytes. Enhances transmitter release at neuromuscular junctions. Apoptosis inhibitor. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF-7) and in myeloid cells. Neurotoxic. Used to study various cellular processes including cell cycle, apoptosis, nitric oxide metabolism and calcium signaling. Stimulates cell motility, loss of stabilization of focal adhesions and a consequent loss of cytoskeletal organization. Source:Isolated from Prorocentrum concavum. Group: Biochemicals. Alternative Names: Halochondrine A, CCRIS 3329, HSDB 7243, 9, 10-Deepithio-9, 10-dide hydroacanthifolicin. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. Molecular Formula: C44H68O13, Molecular Weight: 805. US Biological Life Sciences. | Worldwide |
| Okadaic Acid, Prorocentrum sp. (OA) | An ionophore-like polyether derivative of a C38 fatty acid compound that has tumor promoting properties. Potent inhibitor of protein phosphatase 1 (IC50=10-15nM) and protein phosphatase 2A (IC50=0.1nM). Does not affect the activity of tyrosine phosphatases, alkaline phosphatases, or acid phosphatases. Useful for the study of protein phosphatases in cell extracts as well as in intact cells. Induces apoptosis in human breast carcinoma cells (MB-231 and MCF7) and in myeloid cells but inhibits glucocorticoid-induced apoptosis in T cell hybridomas. Has marked contractile effects on smooth muscle and heart muscle. Implicated as causative agent of diarrhetic shellfish poisoning. Group: Biochemicals. Grades: Highly Purified. CAS No. 78111-17-8. Pack Sizes: 25ug, 100ug. US Biological Life Sciences. | Worldwide |
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