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Vernakalant Quick inquiry Where to buy Suppliers range | Vernakalant is an drug under regulatory for the treatment for conversion of atrial fibrillation. It blocks atrial potassium channels, thereby prolonging repolarization. It differs from typical class III agents and is more effective at high heart rates. It also slightly blocks the hERG potassium channel, leading to a prolonged QT interval. It also blocks atrial sodium channels. It was initially developed by Cardiome Pharma, and the intravenous formulation was bought for further development by Merck in April 2009. In September 2012, Merck terminated its agreements with Cardiome and has consequently returned all rights of the drug back to Cardiome. The drug (under brand name Brinavess) was approved in Europe on 1 September 2010. An oral formulation underwent Phase II clinical trials between 2005 and 2008. Uses: Vernakalant is an drug under regulatory for the treatment for conversion of atrial fibrillation. it blocks atrial potassium channels, thereby prolonging repolarization. it also slightly blocks the herg potassium channel, leading to a prolonged qt interval. it also blocks atrial sodium channels. Synonyms: Brinavess; RSD1235; (3R) -1-[ (1R, 2R) -2-[2- (3, 4-dimethoxyphenyl) ethoxy]cyclohexyl]pyrrolidin-3-ol. Grades: 95%. CAS No. 794466-70-9. Molecular formula: C20H31NO4. Mole weight: 349.47. |