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| Product | Description | |
|---|---|---|
| 8-Oxo-dGDP | 8-Oxo-dGDP, a nucleotide analog, serves as a substrate for DNA polymerases and as a regulator for those enzymes associated with DNA repair in biochemical studies. Furthermore, it is employed to explore the involvement of oxidative stress in cancer and neurodegenerative diseases, such as Alzheimer's and Parkinson's. Synonyms: 8-Oxo-2'-deoxyguanosine-5'-diphosphate, Sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C10H15N5O11P2 (free acid). Mole weight: 443.20 (free acid). |  |
| 8-oxo-dGDP phosphatase | The enzyme catalyses the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. The preferred in vivo substrate is not known. The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55, 8-oxo-dGTP diphosphatase). Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolysed with broad specificity. The bifunctional enzyme NUDT5 also hydrolyses ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13, ADP-ribose diphosphatase). The human enzyme NUDT18 also hydrolyses 8-oxo-dADP and 2-hydroxy-dADP, the latter at a slower rate. Group: Enzymes. Synonyms: NUDT5; MTH3 (gene name); NUDT18. Enzyme Commission Number: EC 3.6.1.58. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4630; 8-oxo-dGDP phosphatase; EC 3.6.1.58; NUDT5; MTH3 (gene name); NUDT18. Cat No: EXWM-4630. |  |
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