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| Product | Description | |
|---|---|---|
| L-Buthionine-(S,R)-sulfoximine | L-Buthionine-(S,R)-sulfoximine. Group: Biochemicals. Alternative Names: (2S) -2-Amino-4- (S-butylsulfonimidoyl) butanoic acid; L-Buthionine sulfoximine; NSC 326231. Grades: Highly Purified. CAS No. 83730-53-4. Pack Sizes: 250mg, 500mg, 1g, 2g, 5g. Molecular Formula: C8H18N2O3S. US Biological Life Sciences. |  Worldwide |
| L-Buthionine sulfoximine | L-Buthionine sulfoximine is an irreversible glutathione-synthesis inhibitor developed as a chemotherapeutic agent. It inhibits glutathione biosynthesis and causes depletion of cellular glutathione levels. Study showed that L-Buthionine sulfoximine synergistically enhanced melphalan activity (inducing 2-4 logs of cell kill) against multiple myeloma cell lines. Synonyms: L-Buthionine-(S,R)-Sulfoximine; (2S)-2-Amino-4-(S-butylsulfonimidoyl)butanoic acid. Grades: ≥98% by HPLC. CAS No. 83730-53-4. Molecular formula: C8H18N2O3S. Mole weight: 222.3. |  |
| L- Buthionine Sulfoximine | A cell-permeable, sulfoximine based compound that acts a potent, fast acting, irreversible inhibitor of g-glutamylcysteine synthetase and depletes cellular glutathione levels. Closely resembles the structure of g-glutamylphosphate cysteine adduct. The inhibition follows the first order kinetics with t1/2 = ~11 sec at saturating inhibitor concentration. Does not affect the activity of glutamine synthetase. Shown to improve the outcome of chemotherapy by lowering the levels of glutathione in cancer cells (IC50 = 1.9, 8.6, and 29uM in melanoma, breast, and ovarian tumor cells, respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 83730-53-4. Pack Sizes: 100mg. Molecular Formula: C?H??N?O?S. US Biological Life Sciences. | Worldwide |
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