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| Product | Description | |
|---|---|---|
| Varlitinib | Varlitinib, also known as ARRY-543, is an orally bioavailable inhibitor of the epidermal growth factor receptor family with potential antineoplastic activity. Varlitinib selectively and reversibly binds to both EGFR (ErbB-1) and Her-2/neu (ErbB-2) and prevents their phosphorylation and activation, which may result in inhibition of the associated signal transduction pathways, inhibition of cellular proliferation and cell death. EGFR and Her-2 play important roles in cell proliferation and differentiation and are upregulated in various human tumor cell types. Due to the dual inhibition of both EGFR and Her-2, this agent may be therapeutically more effective than agents that inhibit EGFR or Her-2 alone. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus). (last updated ). Synonyms: code name: AR 00334543; ARRY-334543; ARRY334543; ARRY-543; ARRY543; ARRY 543. Grades: 0.99. CAS No. 845272-21-1. Molecular formula: C22H19ClN6O2S. Mole weight: 466.944. |  |
| Varlitinib | Varlitinib (ASLAN001) is a potent, reversible, small molecule pan- EGFR inhibitor with IC 50 s of 7, 2, 4 nM for HER1, HER2 and HER4, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASLAN001; ARRY-334543. CAS No. 845272-21-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10530. |  |
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