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NS 8593 hydrochloride NS8593 HCl is a selective KCa2 channel negative modulator. Synonyms: NS 8593 hydrochloride; NS8593 hydrochloride; NS-8593 hydrochloride; N-[(1R)-1,2,3,4-Tetrahydro-1-naphthalenyl]-1H-benzimidazol-2-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 875755-24-1. Molecular formula: C17H17N3.HCl. Mole weight: 299.8. BOC Sciences 10
NS8593 hydrochloride NS8593 hydrochloride is a potent and selective small conductance Ca 2+ -activated K + channels (SK channels) inhibitor. NS8593 hydrochloride reversibly inhibits SK3 -mediated currents with a K d value of 77 nM. NS8593 hydrochloride inhibits all the SK1-3 subtypes Ca 2+ -dependently ( K d s of 0.42, 0.60, and 0.73 μM, respectively, at 0.5 μM Ca 2+ ), and does not affect the Ca 2+ -activated K + channels of intermediate and large conductance (hIK and hBK channels, respectively) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 875755-24-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-110105. MedChemExpress MCE

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