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HIF-2a Translation Inhibitor 76 A cell-permeable HIF-2a translation inhibitor (IC50 value 5 μM). It inhibits HIF-2a translation via enhancing the binding of IRP1 (Iron-Regulatory Protein 1) to the IRE (Iron-Responsive Element) region at the 5' UTR of the HIF-2α mRNA. Synonyms: HIF-2a translation inhibitor; HIF-2|A-IN-4; 882268-69-1; methyl 3-[ (2E) -2-[cyano (methylsulfonyl) methylidene]hydrazinyl]thiophene-2-carboxylate; HIF-2alpha-IN-4; SCHEMBL781448; HMS554D20; Methyl 3- ( ([cyano (methanesulfonyl) methylidene]amino) amino) thiophene-2-carboxylate; CCG-45847; MS-24103; HY-136748; CS-0133535; SR-01000635592-1; methyl 3- (2- (cyano (methylsulfonyl) methylene) hydrazineyl) thiophene-2-carboxylate. Grades: 99%. CAS No. 882268-69-1. Molecular formula: C9H9N3O4S2. Mole weight: 287.32. BOC Sciences 9

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