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| Product | Description | |
|---|---|---|
| SC144 | SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 895158-95-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15614. |  |
| SC144 | SC144 is an orally active small-molecule gp130 inhibitor (C50 = 0.72 μM). Synonyms: SC144; SC 144; SC-144. Grades: >98%. CAS No. 895158-95-9. Molecular formula: C16H11FN6O. Mole weight: 322.3. |  |
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