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| Product | Description | |
|---|---|---|
| LY83583 | LY83583 is an Msp1 inhibitor, a guanylate cyclase inhibitor and a cGMP modulator. LY83583 inhibits soluble guanylate cyclase in human platelets with an IC50 of 2 μM. LY83583 also inhibits leukotriene synthesis in guinea pig lung and rat peritoneal cells with an IC50 of 1.8 μM, and is a noncompetitive inhibitor of glutathione reductase in bovine intestinal mucosa with a Ki of 3 μM. Uses: Enzyme inhibitors. Synonyms: 6-Anilino-5,8-quinolinedione; 6-(Phenylamino)quinoline-5,8-dione; 6-(Phenylamino)-5,8-quinolinedione; 6-Anilinoquinoline-5,8-quinone; 6-(phenylamino)quinoline-5,8-dione. Grades: ≥95%. CAS No. 91300-60-6. Molecular formula: C15H10N2O2. Mole weight: 250.25. |  |
| LY 83583 (LY83583, 6-Anilino-5,8-quinolinequinone) | A cell-permeable, competitive inhibitor of soluble guanylate cyclase (IC50=2uM). Lowers the production of cGMP levels in a wide range of tissues by blocking intracellular Ca2+ release, with negligible effect on cAMP levels. Inhibits nitric oxide-induced smooth muscle relaxation. Shown to inhibit interleukin-1-induced cGMP accumulation in cultured rat aortic vascular smooth muscle cells. Also inhibits neutrophil chemotaxis induced by NO donors. Group: Biochemicals. Grades: Highly Purified. CAS No. 91300-60-6. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
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