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| Product | Description | |
|---|---|---|
| AdipoRon | AdipoRon is an orally active adiponectin receptor (AdipoR) agonist, binding to AdipoR1 and AdipoR2 with K d s of 1.8 and 3.1 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 924416-43-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-15848. |  |
| AdipoRon | AdipoRon is a novel small-molecule AdipoR agonist, binding to both AdipoR1(Kd=1.8 μM) and AdipoR2(Kd=3.1 μM). Synonyms: AdipoRon; 924416-43-3; 2-(4-benzoylphenoxy)-N-(1-benzylpiperidin-4-yl)acetamide; SC-396658; ND7UVH6GKJ. Grades: >98%. CAS No. 924416-43-3. Molecular formula: C27H28N2O3. Mole weight: 428.52. |  |
| AdipoRon (2-(4-Benzoylphenoxy)-N-[1-(phenylmethyl)-4-piperidinyl]acetamide) | Orally-active adiponectin receptor (AdipoR) agonist. Binds to AdipoR1 and AdipoR2 at low um concentration. Activates 5'-adenosine monophosphate-activated protein kinase (AMPK) in cultured mammalian cells. Activates peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1alpha) which boosts mitochondrial proliferation and energy metabolism. Improves diabetes, glucose and lipid metabolism and insulin sensitivity in cultured cells and in mice by AdipoR-dependent mechanisms. Rescued the shortened lifespan of db/db mice (AdipoRs KO) on high-fat diet. Reduces expression levels of genes encoding inflammatory cytokines such as TNF-alpha, IL-6 and CCL-2 in WAT of WT mice but not db/db mice. Group: Biochemicals. Grades: Highly Purified. CAS No. 924416-43-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
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