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| Product | Description | |
|---|---|---|
| Sirtuin-3 Inhibitor, SRT1720 (SIRT3 Inhibitor II, N- (2- (3- (1-Piperazinylmethyl) imidazo[2, 1-b]thiazol-6-yl) phenyl) -2-quinolinecarboxamide) | A cell-permeable quinolinecarboxamide compound that is shown to inhibit the mitochondrial SIRT3 in a substrate AceCS2-competitive (Ki = 0.56uM; Km = 2.44uM), but NAD+-uncompetitive (Ki = 0.34uM; Km = 280uM), manner. Also reported to decrease cellular p53 Lys382 acetylation (Effective conc. = 10uM in U2OS and MEF cultures) and inhibit p300 HAT activity (IC50 = 9uM) in vitro, as well as offer therapeutic benefits in several murine and rodent type 2 diabetes models (100mg/kg/dayl p.o.) in vivo. Whether and how SRT1720 activates SIRT1 activity remains uncertain. Group: Biochemicals. Grades: Highly Purified. CAS No. 925434-55-5. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| SRT1720 | SRT1720 is a drug developed by Sirtris Pharmaceuticals intended as a small-molecule activator of the sirtuin subtype SIRT1. It has similar activity in the body to the known SIRT1 activator resveratrol, but is 1000x more potent. In animal studies it was found to improve insulin sensitivity and lower plasma glucose levels in fat, muscle and liver tissue, and increased mitochondrial and metabolic function. Although SRT1720 is not currently undergoing clinical development, a related compound, SRT2104, is currently in clinical development for metabolic diseases. Synonyms: 2-Quinoxalinecarboxamide, N-[2-[3-(1-piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-; N-[2-[3-(1-Piperazinylmethyl)imidazo[2,1-b]thiazol-6-yl]phenyl]-2-quinoxalinecarboxamide; SRT 1720; SRT-1720. Grades: ≥95%. CAS No. 925434-55-5. Molecular formula: C25H23N7OS. Mole weight: 469.56. |  |
| SRT 1720 | SRT 1720 is a selective activator of human SIRT1 with an EC 1.5 of 0.16 μM, and shows less potent activities for SIRT2 and SIRT3 with EC 1.5 s of 37 μM and > 300 μM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 925434-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10532. |  |
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